Ovarian cancer is the most lethal cause of death among gynecological malignancies. Despite advancements in surgery and chemotherapy treatment strategies, the prognosis of ovarian cancer patients remains poor; a majority of patients relapse and eventually succumb to this disease. Therefore, novel therapeutic approaches to improve patient outcome are urgently needed. The hedgehog signaling pathway is vital for embryonic development and tissue homeostasis, and its deregulation is implicated in cancer cell growth, survival, differentiation, and metastasis. The critical role of hedgehog signaling in multiple biologic processes raises concerns about its potential therapeutic use in cancer. Consequently, many studies are focusing on hedgehog signaling as an attractive target in cancer treatment. In this review, we present an overview of the hedgehog pathway and its pathological aberrations in ovarian cancer. We also discuss inhibitors of the hedgehog signaling pathway that are currently being investigated in the laboratory and in early clinical trials; as well as the clinical challenges these inhibitors face. (C) 2015 Elsevier Ltd. All rights reserved.
第一作者机构：[1]Capital Med Univ, Beijing TianTan Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing TianTan Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Li Haixia,Li Jinghua,Feng Limin.Hedgehog signaling pathway as a therapeutic target for ovarian cancer[J].CANCER EPIDEMIOLOGY.2016,40:152-157.doi:10.1016/j.canep.2015.11.014.
APA：
Li, Haixia,Li, Jinghua&Feng, Limin.(2016).Hedgehog signaling pathway as a therapeutic target for ovarian cancer.CANCER EPIDEMIOLOGY,40,
MLA：
Li, Haixia,et al."Hedgehog signaling pathway as a therapeutic target for ovarian cancer".CANCER EPIDEMIOLOGY 40.(2016):152-157
