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Molecular biomarker-guided anti-angiogenic targeted therapy for malignant glioma

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurosurgery, Peking University International Hospital, Beijing, China [2]Department of Neurosurgery, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China [3]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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关键词： anti-angiogenic biomarkers glioma molecular therapy

摘要：

Despite aggressive multimodality treatment, the prognosis of glioma, especially malignant glioma, remains very poor. After decades of effort, anti-angiogenic therapy has become an important method of cancer treatment in addition to surgery, radiotherapy and chemotherapy. Although the performance of anti-angiogenic therapy in colorectal cancer is good, its performance in malignant glioma remains unsatisfactory. Several phase III clinical trials showed no overall survival benefits. To solve this problem, the division of patients into groups based on their molecular biomarkers is an important step. This paper provides current insights into anti-angiogenic drugs undergoing clinical trials and discusses the potential of molecular biomarkers to guide glioma diagnosis.

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出版当年[2018]版：

大类 | 2 区医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

JCR分区：

出版当年[2017]版：

Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q2 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 4.3 最新[2023版] 5.1 最新五年平均 4.302 出版当年[2017版] 4.252 出版当年五年平均 4.499 出版前一年[2016版] 4.658 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Peking University International Hospital, Beijing, China [2]Department of Neurosurgery, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China

共同第一作者：

通讯作者：

通讯机构： [2]Department of Neurosurgery, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China [3]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [*1]Department of Neurosurgery, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China. [*2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

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