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Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, China [3]School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, China [4]McGill Centre for Studies in Aging, Alzheimer’s Disease Research Unit, Montreal, Canada [5]Banner Alzheimer’s Institute, Phoenix, AZ, USA [6]College of Medicine-Phoenix, University of Arizona, Tucson, AZ, USA [7]School of Mathematics and Statistics, Arizona State University, Tempe, AZ, USA [8]Arizona Alzheimer’s Consortium, Phoenix, AZ, USA

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关键词： Behavioral variant frontotemporal dementia Diffusion tensor imaging Graph theory Network Topology

摘要：

Graph theory is a novel approach used to examine the balance of brain connectomes. However, the clinical relevance of white matter (WM) connectome changes in the behavioral variant frontotemporal dementia (bvFTD) is not well understood. We aimed to investigate the clinical relevance of WM topological alterations in bvFTD. Thirty patients with probable bvFTD and 30 healthy controls underwent diffusion tensor imaging, structural MRI, and neuropsychological assessment. WM connectivity between 90 brain regions was calculated and the graph approach was applied to capture the individual characteristics of the anatomical network. Voxel-based morphometry and tract-based spatial statistics were used to present the gray matter atrophy and disrupted WM integrity. The topological organization was disrupted in patients with bvFTD both globally and locally. Compared to controls, bvFTD data showed a different pattern of hub region distributions. Notably, the nodal efficiency of the right superior orbital frontal gyrus was associated with apathy and disinhibition. Topological measures may be potential image markers for early diagnosis and disease severity monitoring of bvFTD.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 2 区神经科学 3 区老年医学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区老年医学 3 区神经科学

JCR分区：

出版当年[2021]版：

Q2 GERIATRICS & GERONTOLOGY Q2 NEUROSCIENCES

最新[2023]版：

Q2 GERIATRICS & GERONTOLOGY Q2 NEUROSCIENCES

影响因子： 3.7 最新[2023版] 4.1 最新五年平均 5.133 出版当年[2021版] 5.475 出版当年五年平均 4.673 出版前一年[2020版] 4.2 出版后一年[2022版]

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第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China

通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China

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Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia

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