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Colorable role of interleukin (IL)-6 in obesity hypertension: A hint from a Chinese adult case-control study

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wu Ou[a] * ; Yuan Chengda[b] * ; Leng Jianhang[c] ; Zhang Xingyu[d] ; Liu Wei[e] ; Yang Fenfang[c] ; Zhang Hu[f] ; Li Jiajia[g] ; Khederzadeh Saber[h,i] ; Jiang Zhizhi[j] ; Fang Hangyan[k] ; Liu Xiaodong[l] ; Lu Xi[m] ; Xia Jiangwei[n,o] ;
机构： [a]Shulan International Medical College, Zhejiang Shuren University, Zhejiang, China [b]Department of Dermatology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, China [c]Department of Central Laboratory/Medical examination center of Hangzhou, The Frist People’s Hospital of Hangzhou, 310003, Zhejiang, China [d]Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA [e]JFIntelligent Healthcare Technology Co. Ltd, Building No.5-7, No.699 Tianxiang Avenue, Hi-Tech Zone, Nanchang, Jiangxi Province, China [f]Department of Thoracic Surgery, Sir Run Run Shaw Hospital Affiliated with Medical College of Zhejiang University, Zhejiang, China [g]Department of Central Laboratory, the First Affiliated Hospital of Anhui Medical University, Anhui, China [h]Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China [i]Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China [j]ZhaNongKou Street Community Health Service Center, Hangzhou, Zhejiang, China [k]Hangzhou Linping District Center for Disease Prevention and Control, zhejiang, China [l]Hangzhou center for disease control and prevention, Zhejiang, China [m]Hangzhou Vocational and Technical College, Zhejiang, China [n]Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China [o]Beijing Municipal Geriatric Medical Research Center, Beijing, China
出处：
DOI： 10.1016/j.cyto.2023.156226
ISSN：

关键词： interleukin (IL)-6 Obesity Hypertension Blood pressure Body mass index

摘要：
Obesity and hypertension are major risk factors for cardiovascular diseases that affect millions of people worldwide. Both conditions are associated with chronic low-grade inflammation, which is mediated by cytokines such as interleukin-6 (IL-6). IL-6 is a multifunctional cytokine that can have pro-inflammatory or anti-inflammatory effects depending on the context. The exact role of IL-6 in obesity-associated hypertension is unclear.To investigate how IL-6 affects blood pressure, inflammation, and metabolic function in obesity-hypertension using a Chinese adult case-control study.A total of 153 participants were sorted into four subgroups according to their body mass index (BMI) and blood pressure (BP): normal healthy group (NH), just obesity group (JO), just-hypertension group (JH), and obesity-hypertension group (OH). Serum IL-6 concentrations were measured by Enzyme-linked Immunosorbent Assay (ELISA) and their correlations with anthropometric and laboratory parameters and their differences across the subgroups were examined. Multiple linear regression analysis was performed to identify the predictors of serum IL-6 concentrations in each group.Serum IL-6 concentrations were higher in NH group than in JO group and correlated positively with diastolic blood pressure in NH and JO groups, but not in JH and OH groups. Serum IL-6 concentrations also correlated with albumin in NH group, alkaline phosphatase in JO group, serum creatinine and fasting blood glucose in JH group. The influencing factors of serum IL-6 concentrations varied among the four groups, with gender, diastolic blood pressure and albumin being significant predictors in NH group, alkaline phosphatase in JO group, age and serum creatinine in JH group, and none in OH group.These results suggest that IL-6 may play diverse effects in the pathogenesis of obesity- hypertension, depending on the presence or absence of obesity and hypertension. Further studies are needed to elucidate the underlying mechanisms of IL-6 signaling and function in these diseases.Copyright © 2023 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China (81102200), and “Teacher professional development project” for domestic visiting scholars in colleges and universities of Zhejiang Province in 2020[2020043] Zhejiang Philosophy and Social Science Planning Foundation [19NDJC069YB].
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 生化与分子生物学 3 区 细胞生物学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 生化与分子生物学 3 区 细胞生物学 3 区 免疫学
JCR分区：
出版当年[2021]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY Q3 IMMUNOLOGY
最新[2023]版：
Q2 CELL BIOLOGY Q2 IMMUNOLOGY Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [a]Shulan International Medical College, Zhejiang Shuren University, Zhejiang, China
共同第一作者：
通讯作者：
通讯机构： [n]Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China [o]Beijing Municipal Geriatric Medical Research Center, Beijing, China
推荐引用方式(GB/T 7714)：
Wu Ou,Yuan Chengda,Leng Jianhang,et al.Colorable role of interleukin (IL)-6 in obesity hypertension: A hint from a Chinese adult case-control study[J].CYTOKINE.2023,168:doi:10.1016/j.cyto.2023.156226.
APA：
Wu Ou,Yuan Chengda,Leng Jianhang,Zhang Xingyu,Liu Wei...&Xia Jiangwei.(2023).Colorable role of interleukin (IL)-6 in obesity hypertension: A hint from a Chinese adult case-control study.CYTOKINE,168,
MLA：
Wu Ou,et al."Colorable role of interleukin (IL)-6 in obesity hypertension: A hint from a Chinese adult case-control study".CYTOKINE 168.(2023)

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