详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Genetic correlation, causal relationship, and shared loci between vitamin D and COVID-19: A genome-wide cross-trait analysis

111| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China. [2]School of Life Science and Technology, Harbin Institute of Technology, Harbin, China. [3]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China. [4]Chinese Institute for Brain Research, Beijing, China. [5]Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Department of Neurology, Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, China. [6]Beijing Key Laboratory of Hypoxia Translational Medicine, National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing, China.

出处：

DOI：

ISSN：

关键词： COVID‐19 genome‐wide association study Mendelian randomization molecular docking vitamin D

摘要：

Observational studies have shown that vitamin D supplementation reduces the risk of COVID-19 infection, yet little is known about the shared genomic architectures between them. Leveraging large-scale genome-wide association study (GWAS) summary statistics, we investigated the genetic correlation and causal relationship between genetically determined vitamin D and COVID-19 using linkage disequilibrium score regression and Mendelian randomization (MR) analyses, and conducted a cross-trait GWAS meta-analysis to identify the overlapping susceptibility loci of them. We observed a significant genetic correlation between genetically predicted vitamin D and COVID-19 (rg = -0.143, p = 0.011), and the risk of COVID-19 infection would decrease by 6% for every 0.76 nmol L-1 increase of serum 25 hydroxyvitamin D (25OHD) concentrations in generalized MR (OR = 0.94, 95% CI: 0.89-0.99, p = 0.019). We identified rs4971066 (EFNA1) as a risk locus for the joint phenotype of vitamin D and COVID-19. In conclusion, genetically determined vitamin D is associated with COVID-19. Increased levels of serum 25OHD concentration may benefit the prevention and treatment of COVID-19.© 2023 Wiley Periodicals LLC.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区病毒学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区病毒学

JCR分区：

出版当年[2021]版：

Q1 VIROLOGY

最新[2023]版：

Q1 VIROLOGY

影响因子： 6.8 最新[2023版] 6.6 最新五年平均 20.693 出版当年[2021版] 12.203 出版当年五年平均 2.327 出版前一年[2020版] 12.7 出版后一年[2022版]

第一作者：

第一作者机构： [1]School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.

通讯作者：

通讯机构： [1]School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China. [3]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China. [4]Chinese Institute for Brain Research, Beijing, China. [5]Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Department of Neurology, Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, China. [6]Beijing Key Laboratory of Hypoxia Translational Medicine, National Engineering Laboratory of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Capital Medical University, Beijing, China. [*1]School of Computer Science and Technology, Harbin Institute of Technology, Yikuang St 2, Nangang District, Harbin 150001, China. [*2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Genetic correlation, causal relationship, and shared loci between vitamin D and COVID-19: A genome-wide cross-trait analysis

文献详情

相关文献