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Neurological adverse events associated with PD-1/PD-L1 immune checkpoint inhibitors

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收录情况： ◇ SCIE

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机构： [1]Xuanwu Hosp, Gen Surg Dept, Beijing, Peoples R China

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关键词： PD-1 neurotoxin ICIs adverse events immunotherapy

摘要：

Immunotherapy is a promising method for cancer treatment. Among them, immune checkpoint inhibitors targeting PD-1/PD-L1 are increasingly used for certain cancers. However, with the widespread use of such drugs, reports of immune-related adverse events (irAEs) are also increasing. Neurological adverse events (nAEs) are one of the irAEs that affect the peripheral and central nervous systems. They are characterized by low incidence, hard to diagnose, and life-threatening risks, which have a significant impact on the prognosis of patients. Biomarker-based early diagnosis and subsequent treatment strategies are worthy of attention, and comprehensive management of irAEs is important for optimizing patients' quality of life and long-term outcomes. In this review, we summarized the mechanisms, common symptoms, early biomarkers, treatments, and future research directions of nAEs, in order to provide a comprehensive overview of immune checkpoint inhibitor-related nAEs targeting PD-1/PD-L1.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学

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出版当年[2021]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 3.2 最新[2023版] 4.3 最新五年平均 5.152 出版当年[2021版] 5.582 出版当年五年平均 4.677 出版前一年[2020版] 4.3 出版后一年[2022版]

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第一作者机构： [1]Xuanwu Hosp, Gen Surg Dept, Beijing, Peoples R China

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