机构：[1]Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China[2]Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China[3]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, China外科系统骨科首都医科大学宣武医院[4]Department of Orthopedics, Huzhou Central Hospital, Huzhou 313099, China[5]Department of Orthopedics, Huzhou Basic and Clinical Translation of Orthopaedics Key Laboratory, Huzhou 313099, China[6]The Institute of Life Sciences, Wenzhou University, Wenzhou 325035, China[7]Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou, Zhejiang 325000, China
CNS (central nervous system) trauma, which is classified as SCI (spinal cord injury) and TBI (traumatic brain injury), is gradually becoming a major cause of accidental death and disability worldwide. Many previous studies have verified that the pathophysiological mechanism underlying cell death and the subsequent neuroinflammation caused by cell death are pivotal factors in the progression of CNS trauma. Simultaneously, EVs (extracellular vesicles), membrane-enclosed particles produced by almost all cell types, have been proven to mediate cell-to-cell communication, and cell death involves complex interactions among molecules. EVs have also been proven to be effective carriers of loaded bioactive components to areas of CNS trauma. Therefore, EVs are promising therapeutic targets to cure CNS trauma. However, the link between EVs and various types of cell death in the context of CNS trauma remains unknown. Therefore, in this review, we summarize the mechanism underlying EV effects, the relationship between EVs and cell death and the pathophysiology underlying EV effects on the CNS trauma based on information in published papers. In addition, we discuss the prospects of applying EVs to the CNS as feasible therapeutic strategies for CNS trauma in the future.
基金：
This work was funded by grants from the National Natural
Science Foundation of China (No. 82072192 to Kailiang Zhou);
Wenzhou Science and Technology Bureau Foundation (No. Y20210438
to Kailiang Zhou); Public Welfare Technology Application Research
Project of Zhejiang Province (LGF20H150003 to Kailiang Zhou); and
Zhejiang Provincial Natural Science Foundation (No. LY17H060009
to Wenfei Ni).
第一作者机构：[1]Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China[2]Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China[2]Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China[7]Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 West Xueyuan Road, Wenzhou, Zhejiang 325000, China
推荐引用方式(GB/T 7714)：
Chen Yituo,Zhang Haojie,Hu Xinli,et al.Extracellular Vesicles: Therapeutic Potential in Central Nervous System Trauma by Regulating Cell Death[J].MOLECULAR NEUROBIOLOGY.2023,60(12):6789-6813.doi:10.1007/s12035-023-03501-w.
APA：
Chen, Yituo,Zhang, Haojie,Hu, Xinli,Cai, Wanta,Jiang, Liting...&Zhou, Kailiang.(2023).Extracellular Vesicles: Therapeutic Potential in Central Nervous System Trauma by Regulating Cell Death.MOLECULAR NEUROBIOLOGY,60,(12)
MLA：
Chen, Yituo,et al."Extracellular Vesicles: Therapeutic Potential in Central Nervous System Trauma by Regulating Cell Death".MOLECULAR NEUROBIOLOGY 60..12(2023):6789-6813
