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As a potential predictor of pan-cancer, UBE2S is related to tumor-associated macrophage infiltration

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机构： [1]Department of Center for Clinical Single Cell Biomedicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China. [2]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 1000053, China. [3]Department of Gynecology, Shijitan Hospital, Capital Medical University, Beijing, 1000038, China. [4]Department of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

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关键词： bioinformatics analysis pan-cancer prognostic value tumor-associated macrophages ubiquitin-conjugating enzyme E2S

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Background: At the pan-cancer level, exploring the expression and prognostic significance of a gene, such as UBE2S, will help to gain insight into the role of the gene and its feasibility for cancer screening, prognosis assessment and even gene therapy. Methods: The Cancer Genome Atlas, Human Protein Atlas, Kaplan-Meier, Tumor Immunology Estimation Resource and other databases were used to analyze the expression of UBE2S at the pan-cancer level, its prognosis and the role of the immune microenvironment. Immunohistochemistry samples of tumor tissue collected in our clinic were taken as verification. Results: UBE2S is significantly overexpressed in pan-cancer and is closely associated with malignant clinical features, poor prognosis and tumor-associated macrophages. Conclusion: UBE2S may be a potential diagnostic and prognostic marker for pan-cancer and is associated with tumor-associated macrophages.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2021]版：

Q3 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3 最新[2023版] 2.9 最新五年平均 3.674 出版当年[2021版] 3.392 出版当年五年平均 3.404 出版前一年[2020版] 3.3 出版后一年[2022版]

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第一作者机构： [1]Department of Center for Clinical Single Cell Biomedicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China.

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