Transcriptional factor Sox2 promotes tumor metastasis; however its regulatory effect on tumor-associated macrophages (TAMs, M2 phenotype) has not been defined. This study disclosed concomitant expression of TAMs marker-CD163 with SOX2 in human breast cancer and showed that Sox2 in breast cancer cells promotes recruitment of TAMs with altered expression of multiple chemokines, including MIP-1 alpha, ICAM-1 etc. and activation of Stat3 and NF-kappa B signalings. In addition, TAMs rescued the compromised lung metastasis induced by Sox2 silencing in breast cancer cells. Together, this study documented that Sox2 plays an important role in recruiting TAMs and promotes tumor metastasis in a TAMs dependent manner. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
基金：
NSFCNational Natural Science Foundation of China [81372308]; China 973 programNational Basic Research Program of China [2013CB967201]; China International Cooperation Research Program [2012DFA10650]
第一作者机构：[1]Nankai Univ, Sch Med, Tianjin 300071, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing 100045, Peoples R China;[5]Chinese Peoples Liberat Army Gen Hosp, Dept Biochem, Beijing 100853, Peoples R China;
通讯作者：
通讯机构：[1]Nankai Univ, Sch Med, Tianjin 300071, Peoples R China;[6]Tianjin Key Lab Tumor Microenvironm & Neurovasc R, Tianjin 300071, Peoples R China;[7]Nankai Univ, Collaborat Innovat Ctr Biotherapy, Tianjin 300071, Peoples R China;[8]Nankai Univ, Sch Med, 94 Weijin Rd, Tianjin 300071, Peoples R China
推荐引用方式(GB/T 7714)：
Mou Wenjun,Xu Yingxi,Ye Yujie,et al.Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment[J].CANCER LETTERS.2015,358(2):115-123.doi:10.1016/j.canlet.2014.11.004.
APA：
Mou, Wenjun,Xu, Yingxi,Ye, Yujie,Chen, Si,Li, Xuefei...&Li, Na.(2015).Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment.CANCER LETTERS,358,(2)
MLA：
Mou, Wenjun,et al."Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment".CANCER LETTERS 358..2(2015):115-123
医学