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The dual role of microglia in neuropathic pain after spinal cord injury: Detrimental and protective effects

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Sun Chang[1,2,3] * ; Deng Junhao[1,2,4,5,6] * ; Ma Yifei[7] ; Meng Fanqi[8] ; Cui Xiang[1,2] ; Li Ming[1,2] ; Li Jiantao[1,2] ; Li Jia[1,2] ; Yin Pengbin[1,2] ; Kong Lingjie[5,6,*1] ; Zhang Licheng[1,2,*1] ; Tang Peifu[1,2,*1] ;
机构： [1]Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China [2]National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, Beijing, China [3]Department of Orthopedics, Air Force Medical Center, PLA, Beijing, China [4]School of Life Sciences, Tsinghua University, Beijing, China [5]State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, China [6]IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China [7]School of Medicine, Nankai University, Tianjin, China h Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1016/j.expneurol.2023.114570
ISSN：

关键词： Spinal cord injury Neuropathic pain Microglia Central nervous system

摘要：
Spinal cord injury (SCI) is a debilitating condition that is frequently accompanied by neuropathic pain, resulting in significant physical and psychological harm to a vast number of individuals globally. Despite the high prevalence of neuropathic pain following SCI, the precise underlying mechanism remains incompletely understood. Microglia are a type of innate immune cell that are present in the central nervous system (CNS). They have been observed to have a significant impact on neuropathic pain following SCI. This article presents a comprehensive overview of recent advances in understanding the role of microglia in the development of neuropathic pain following SCI. Specifically, the article delves into the detrimental and protective effects of microglia on neuropathic pain following SCI, as well as the mechanisms underlying their interconversion. Furthermore, the article provides a thorough overview of potential avenues for future research in this area.Copyright © 2023. Published by Elsevier Inc.

基金：
This work is supported by the National Natural Science Foundation of China (No. 82272478 to P.T.).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
JCR分区：
出版当年[2021]版：
Q2 NEUROSCIENCES
最新[2023]版：
Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China [2]National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, Beijing, China [3]Department of Orthopedics, Air Force Medical Center, PLA, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China [2]National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, Beijing, China [5]State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, China [6]IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China [*1]Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China [*2]State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing, China.
推荐引用方式(GB/T 7714)：
Sun Chang,Deng Junhao,Ma Yifei,et al.The dual role of microglia in neuropathic pain after spinal cord injury: Detrimental and protective effects[J].EXPERIMENTAL NEUROLOGY.2023,370:doi:10.1016/j.expneurol.2023.114570.
APA：
Sun Chang,Deng Junhao,Ma Yifei,Meng Fanqi,Cui Xiang...&Tang Peifu.(2023).The dual role of microglia in neuropathic pain after spinal cord injury: Detrimental and protective effects.EXPERIMENTAL NEUROLOGY,370,
MLA：
Sun Chang,et al."The dual role of microglia in neuropathic pain after spinal cord injury: Detrimental and protective effects".EXPERIMENTAL NEUROLOGY 370.(2023)

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