Immunotherapy and Hypofractionated Radiotherapy in Older Patients with Locally Advanced Cutaneous Squamous-Cell Carcinoma of the Head and Neck: A Proposed Paradigm by the International Geriatric Radiotherapy Group
机构：[1]Department of Radiation Oncology, Howard University, Washington, DC 20059, USA.[2]Department of Radiation Oncology, Francois Baclesse Cancer Center, 14000 Cain, France.[3]Department of Oral Surgery, University of Martinique, 97213 Martinique, France.[4]Department of Radiation Oncology, Institut Bergonie, 33076 Bordeaux, France.[5]Division of Neuro-Oncology, Mount Sinai Hospital, New York, NY 10029, USA.[6]Department of Oral and Maxillofacial Surgery, Howard University, Washington, DC 20059, USA.[7]Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.[8]Department of Radiation Oncology, Sant Joan de Reus University Hospital, University of Rovira, I Virgili, 43204 Tarragona, Spain.[9]Department of Radiation Oncology, International Geriatric Radiotherapy Group, Washington, DC 20001, USA.[10]Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC 29425, USA.[11]Department of Surgery, Southern Regional Health System, Lawrenceburg, TN 29425, USA.[12]Department of Radiation Oncology, Xuanwu Hospital, Capital Medical University, Beijing 101125, China.首都医科大学宣武医院[13]Department of Radiation Oncology, CHU Mondor, 94000 Creteil, France.[14]Colorectal Research Center, Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.[15]Department of Radiation Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, UK.[16]Division of Cancer Sciences, Faculty of Biomedicine and Health, School of Medical Sciences, The University of Manchester, Manchester M13 9PL, UK.[17]Division of Hematology Oncology, Howard University, Washington, DC 20059, USA.[18]Department of Radiation Oncology, Johns Hopkins University, Baltimore 21218, MD, USA.
Cutaneous skin carcinoma is a disease of older patients. The prevalence of cutaneous squamous-cell carcinoma (cSCC) increases with age. The head and neck region is a frequent place of occurrence due to exposure to ultraviolet light. Surgical resection with adjuvant radiotherapy is frequently advocated for locally advanced disease to decrease the risk of loco-regional recurrence. However, older cancer patients may not be candidates for surgery due to frailty and/or increased risk of complications. Radiotherapy is usually advocated for unresectable patients. Compared to basal-cell carcinoma, locally advanced cSCC tends to recur locally and/or can metastasize, especially in patients with high-risk features such as poorly differentiated histology and perineural invasion. Thus, a new algorithm needs to be developed for older patients with locally advanced head and neck cutaneous squamous-cell carcinoma to improve their survival and conserve their quality of life. Recently, immunotherapy with checkpoint inhibitors (CPIs) has attracted much attention due to the high prevalence of program death ligand 1 (PD-L1) in cSCC. A high response rate was observed following CPI administration with acceptable toxicity. Those with residual disease may be treated with hypofractionated radiotherapy to minimize the risk of recurrence, as radiotherapy may enhance the effect of immunotherapy. We propose a protocol combining CPIs and hypofractionated radiotherapy for older patients with locally advanced cutaneous head and neck cancer who are not candidates for surgery. Prospective studies should be performed to verify this hypothesis.
第一作者机构：[1]Department of Radiation Oncology, Howard University, Washington, DC 20059, USA.
通讯作者：
推荐引用方式(GB/T 7714)：
Nguyen Nam P,Thariat Juliette,Gorobets Olena,et al.Immunotherapy and Hypofractionated Radiotherapy in Older Patients with Locally Advanced Cutaneous Squamous-Cell Carcinoma of the Head and Neck: A Proposed Paradigm by the International Geriatric Radiotherapy Group[J].CANCERS.2023,15(20):doi:10.3390/cancers15204981.
APA：
Nguyen Nam P,Thariat Juliette,Gorobets Olena,Vinh-Hung Vincent,Kim Lyndon...&Page Brandi R.(2023).Immunotherapy and Hypofractionated Radiotherapy in Older Patients with Locally Advanced Cutaneous Squamous-Cell Carcinoma of the Head and Neck: A Proposed Paradigm by the International Geriatric Radiotherapy Group.CANCERS,15,(20)
MLA：
Nguyen Nam P,et al."Immunotherapy and Hypofractionated Radiotherapy in Older Patients with Locally Advanced Cutaneous Squamous-Cell Carcinoma of the Head and Neck: A Proposed Paradigm by the International Geriatric Radiotherapy Group".CANCERS 15..20(2023)
医学