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Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential

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机构: [1]Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China [2]Xuanwu Hosp, Beijing Key Lab Innovat Drug Discovery Tradit Chin, Beijing, Peoples R China [3]Minist Educ, Key Lab Bioact Subst & Resource Utilizat Chinese H, Beijing, Peoples R China
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关键词: Extracellular vesicles Vascular disease Intercellular communication Clinical application Targets Biomarkers

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BackgroundCells have been increasingly known to release extracellular vesicles (EVs) to the extracellular environment under physiological and pathological conditions. A plethora of studies have revealed that EVs contain cell-derived biomolecules and are found in circulation, thereby implicating them in molecular trafficking between cells. Furthermore, EVs have an effect on physiological function and disease development and serve as disease biomarkers.Main bodyGiven the close association between EV circulation and vascular disease, this review aims to provide a brief introduction to EVs, with a specific focus on the EV cargoes participating in pathological mechanisms, diagnosis, engineering, and clinical potential, to highlight the emerging evidence suggesting promising targets in vascular diseases. Despite the expansion of research in this field, some noticeable limitations remain for clinical translational research.ConclusionThis review makes a novel contribution to a summary of recent advances and a perspective on the future of EVs in vascular diseases.ELz9YnYAYFY99CoHEpsS2QVideo AbstractConclusionThis review makes a novel contribution to a summary of recent advances and a perspective on the future of EVs in vascular diseases.ELz9YnYAYFY99CoHEpsS2QVideo Abstract

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出版当年[2022]版:
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
最新[2023]版:
大类 | 2 区 生物学
小类 | 2 区 细胞生物学
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出版当年[2021]版:
Q2 CELL BIOLOGY
最新[2023]版:
Q1 CELL BIOLOGY

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第一作者机构: [1]Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China [2]Xuanwu Hosp, Beijing Key Lab Innovat Drug Discovery Tradit Chin, Beijing, Peoples R China [3]Minist Educ, Key Lab Bioact Subst & Resource Utilizat Chinese H, Beijing, Peoples R China
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通讯机构: [1]Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China [2]Xuanwu Hosp, Beijing Key Lab Innovat Drug Discovery Tradit Chin, Beijing, Peoples R China [3]Minist Educ, Key Lab Bioact Subst & Resource Utilizat Chinese H, Beijing, Peoples R China
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