机构:[1]Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China[2]Xuanwu Hosp, Beijing Key Lab Innovat Drug Discovery Tradit Chin, Beijing, Peoples R China首都医科大学宣武医院[3]Minist Educ, Key Lab Bioact Subst & Resource Utilizat Chinese H, Beijing, Peoples R China
BackgroundCells have been increasingly known to release extracellular vesicles (EVs) to the extracellular environment under physiological and pathological conditions. A plethora of studies have revealed that EVs contain cell-derived biomolecules and are found in circulation, thereby implicating them in molecular trafficking between cells. Furthermore, EVs have an effect on physiological function and disease development and serve as disease biomarkers.Main bodyGiven the close association between EV circulation and vascular disease, this review aims to provide a brief introduction to EVs, with a specific focus on the EV cargoes participating in pathological mechanisms, diagnosis, engineering, and clinical potential, to highlight the emerging evidence suggesting promising targets in vascular diseases. Despite the expansion of research in this field, some noticeable limitations remain for clinical translational research.ConclusionThis review makes a novel contribution to a summary of recent advances and a perspective on the future of EVs in vascular diseases.ELz9YnYAYFY99CoHEpsS2QVideo AbstractConclusionThis review makes a novel contribution to a summary of recent advances and a perspective on the future of EVs in vascular diseases.ELz9YnYAYFY99CoHEpsS2QVideo Abstract
基金:
National Key Research and Development Project [2022YFC3501105]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2022-I2M-2-002]; Major Program of the National Natural Science Foundation of China [81891012]
第一作者机构:[1]Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China[2]Xuanwu Hosp, Beijing Key Lab Innovat Drug Discovery Tradit Chin, Beijing, Peoples R China[3]Minist Educ, Key Lab Bioact Subst & Resource Utilizat Chinese H, Beijing, Peoples R China
通讯作者:
通讯机构:[1]Peking Union Med Coll & Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China[2]Xuanwu Hosp, Beijing Key Lab Innovat Drug Discovery Tradit Chin, Beijing, Peoples R China[3]Minist Educ, Key Lab Bioact Subst & Resource Utilizat Chinese H, Beijing, Peoples R China
推荐引用方式(GB/T 7714):
Liu Wenxiu,Jin Meiqi,Chen Qiuyan,et al.Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential[J].CELL COMMUNICATION AND SIGNALING.2023,21(1):doi:10.1186/s12964-023-01304-z.
APA:
Liu, Wenxiu,Jin, Meiqi,Chen, Qiuyan,Li, Qiaoyu,Xing, Xiaoyan...&Sun, Xiaobo.(2023).Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential.CELL COMMUNICATION AND SIGNALING,21,(1)
MLA:
Liu, Wenxiu,et al."Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential".CELL COMMUNICATION AND SIGNALING 21..1(2023)