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Cognitive impairment in cerebral small vessel disease induced by hypertension

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收录情况: ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越:梯队期刊

机构: [1]Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center [3]Beijing Engineering Research Center for NervousSystem Drugs [4]National Center for Neurological Disorders [5]National Clinical Research Center for Geriatric Diseases, Beijing, China
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关键词: blood-brain barrier cerebral small vessel disease cognitive impairment dementia endothelial dysfunction enlarged perivascular space hypertension lacunar infarction neuroinflammation treatment white matter highsignal intensity

摘要:
Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease, the most common cerebrovascular disease. However, the causal relationship between hypertension and cerebral small vessel disease remains unclear. Hypertension has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular disease. Chronic hypertension and lifestyle factors are associated with risks for stroke and dementia, and cerebral small vessel disease can cause dementia and stroke. Hypertension is the main driver of cerebral small vessel disease, which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction, leukoaraiosis, white matter lesions, and intracerebral hemorrhage, ultimately resulting in cognitive decline and demonstrating that the brain is the target organ of hypertension. This review updates our understanding of the pathogenesis of hypertension-induced cerebral small vessel disease and the resulting changes in brain structure and function and declines in cognitive ability. We also discuss drugs to treat cerebral small vessel disease and cognitive impairment.Copyright © 2024 Copyright: © 2024 Neural Regeneration Research.

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出版当年[2023]版:
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 神经科学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 神经科学
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出版当年[2022]版:
Q1 NEUROSCIENCES Q2 CELL BIOLOGY
最新[2023]版:
Q1 NEUROSCIENCES Q2 CELL BIOLOGY

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第一作者机构: [1]Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center [3]Beijing Engineering Research Center for NervousSystem Drugs [4]National Center for Neurological Disorders [5]National Clinical Research Center for Geriatric Diseases, Beijing, China
通讯作者:
通讯机构: [1]Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center [3]Beijing Engineering Research Center for NervousSystem Drugs [4]National Center for Neurological Disorders [5]National Clinical Research Center for Geriatric Diseases, Beijing, China
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