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In vitro differentiation of human CD45+ CD34+ induced hematopoietic progenitor cells from iPSCs using a monolayer system

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Liu Zhongfeng[1,2,4] * ; Liu Weihua[1,2,3] * ; Chen Zhiguo[1,2,*1] ; Kang Hua[4] ;
机构： [1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China [2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China [3]Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen 518055, China [4]Department of General Surgery, Center for Thyroid and Breast Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
出处：
DOI： 10.1016/j.transci.2023.103866
ISSN：

关键词： Induced hematopoietic progenitor cells (iHPC) Induced pluripotent stem cells (iPSCs) Extracellular matrix Glass material

摘要：
Hematopoietic stem cells (HSCs) represent crucial target cells in the management of hematopoietic and immune system disorders. Unfortunately, the primary source of hematopoietic stem cells is limited. Hematopoietic stem cells derived from induced pluripotent stem cells (iPSCs) hold great promise for applications in cell therapy, disease modeling, and drug screening. To achieve a consistent induction method, one specific induction scheme capable of reliably generating CD34 and CD45 double-positive cells from iPSCs was optimized, employing a comparative analysis and screening of various induction methods. The comprehensive induction procedures are outlined in this document.Copyright © 2024 Elsevier Ltd. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (82171250 and 81973351), Beijing Talents Foundation (2017000021223TD03), Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan (CIT & TCD20180333), Beijing Municipal Health Commission Fund (PXM2020_026283_000005), Beijing One Hundred, Thousand, and Ten Thousand Talents Fund (2018A03), and the Royal Society-Newton Advanced Fellowship (NA150482).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 血液学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 血液学
JCR分区：
出版当年[2022]版：
Q4 HEMATOLOGY
最新[2023]版：
Q4 HEMATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China [2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China [4]Department of General Surgery, Center for Thyroid and Breast Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构： [1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China [2]Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing 100069, China [*1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China
推荐引用方式(GB/T 7714)：
Liu Zhongfeng,Liu Weihua,Chen Zhiguo,et al.In vitro differentiation of human CD45+ CD34+ induced hematopoietic progenitor cells from iPSCs using a monolayer system[J].TRANSFUSION AND APHERESIS SCIENCE.2024,63(1):103866.doi:10.1016/j.transci.2023.103866.
APA：
Liu Zhongfeng,Liu Weihua,Chen Zhiguo&Kang Hua.(2024).In vitro differentiation of human CD45+ CD34+ induced hematopoietic progenitor cells from iPSCs using a monolayer system.TRANSFUSION AND APHERESIS SCIENCE,63,(1)
MLA：
Liu Zhongfeng,et al."In vitro differentiation of human CD45+ CD34+ induced hematopoietic progenitor cells from iPSCs using a monolayer system".TRANSFUSION AND APHERESIS SCIENCE 63..1(2024):103866

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