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18F-FP-DTBZ PET/CT detectable associations between monoaminergic depletion in the putamen with rigidity and the pallidus with tremor in Parkinson's disease

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Chinese Institute for Brain Research (CIBR), Beijing, China. [3]University of Paris-Saclay, The French Alternative Energies and Atomic Energy Commission, The French National Center for Scientific Research, Molecular Imaging Research Center, Laboratory of Neurodegenerative Diseases, Fontenay-aux-Roses, France. [4]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [5]Mental Health PET Radioligand Development Program, Yale University, New Haven, USA [6]Xingimaging, 150 Boston Post Road, Madison, LCC, Connecticut, USA [7]National Clinical Research Center for Geriatric Diseases, Beijing, China.

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关键词： Motor subtype Parkinson’s disease Tremor PET Monoamine

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The motor subtypes of Parkinson's disease (PD) are widely accepted and implemented. However, the motor subtypes have been thought to represent different stages of PD recently because some patients experience tremor-dominant (TD) conversion to the non-tremor-dominant subtype, such as postural instability-gait difficulty (PIGD). In this study, we explore the monoaminergic denervation features of the striatal and extra-striatal areas in patients with different subtypes of PD with 18F-9-fluoropropyl-(+)-dihydrotetrabenazine (18F-FP-DTBZ) PET/CT.Sixty-five patients diagnosed with PD were included and classified as TD (n = 25) and PIGD (n = 40). We evaluated the difference of monoaminergic features of each subregion of brain between motor subtypes of PD, as well as associations between these features and Parkinsonian motor symptoms.The striatal standardized uptake value ratios (SUVR) showed that dopaminergic disruption of patients with PIGD was more symmetrical in the posterior ventral putamen (p < 0.001) and more severe in the ipsilateral posterior dorsal putamen (p < 0.001 corrected) compared with that of patients with TD. The severity of PIGD scores was associated with striatal dopaminergic depletion, while tremor was associated with monoaminergic changes in extra-striatal areas, including pallidus, thalamus, and raphe nuclie.These results indicate that patients with different motor subtypes may have different underlying mechanisms of PD pathogenesis. Therefore, accurate diagnosis of PD subtypes can aid prognosis evaluation and treatment decision-making.Copyright © 2024 Elsevier Ltd. All rights reserved.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区临床神经病学

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出版当年[2022]版：

Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q2 CLINICAL NEUROLOGY

影响因子： 3.1 最新[2023版] 3.8 最新五年平均 4.1 出版当年[2022版] 4.4 出版当年五年平均 4.402 出版前一年[2021版] 3.1 出版后一年[2023版]

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第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

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通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [7]National Clinical Research Center for Geriatric Diseases, Beijing, China.

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18F-FP-DTBZ PET/CT detectable associations between monoaminergic depletion in the putamen with rigidity and the pallidus with tremor in Parkinson's disease

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