详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

IDH1 mutation predicts seizure occurrence and prognosis in lower-grade glioma adults

54| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing 100053, China. [2]Clinical Research Center for Epilepsy, Capital Medical University, Beijing 100053, China. [3]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China.

出处：

DOI：

ISSN：

关键词： Epilepsy Glioma Isocitrate dehydrogenase Engel classification

摘要：

Epileptic seizures are frequently the first symptom in glioma patients. However, the causal relationship between glioma and epilepsy is not yet fully understood, as it cannot be explained solely by tumor mass effect or peritumoral factors. In this study, we retrospectively enrolled 320 patients with grade 2-4 glioma who received treatment between January 2019 and July 2022, and explored the biomarkers of seizure occurrence and seizure outcome prediction using univariate and multivariate logistic regression analyses. Our results showed that IDH1 R132H mutation was an independent risk factor for seizure occurrence in lower-grade glioma (LGG) patients (OR = 4.915, 95%CI = 1.713 - 14.103, P = 0.003). Additionally, IDH1 R132H mutation predicted higher seizure-free ratios in LGG patients with intact ATRX expression (OR = 6.793, 95%CI = 1.217 - 37.923, P = 0.029) one year after diagnosis. Therefore, our findings suggest that IDH1 mutation can predict seizure occurrence and control in LGG patients, providing further insights into the relationship between glioma and epilepsy.Copyright © 2024. Published by Elsevier GmbH.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区病理学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区病理学

JCR分区：

出版当年[2022]版：

Q2 PATHOLOGY

最新[2023]版：

Q2 PATHOLOGY

影响因子： 2.9 最新[2023版] 2.6 最新五年平均 2.8 出版当年[2022版] 2.7 出版当年五年平均 3.309 出版前一年[2021版] 2.9 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing 100053, China.

通讯作者：

通讯机构： [1]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing 100053, China. [2]Clinical Research Center for Epilepsy, Capital Medical University, Beijing 100053, China. [3]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Anatomical localization of isocitrate dehydrogenase 1 mutation: a voxel-based radiographic study of 146 low-grade gliomas [2]IDH1R132H在中枢神经系统胶质瘤中的表达及其鉴别诊断意义 [3]慢病毒介导的异柠檬酸脱氢酶1基因R132H突变过表达抑制脑胶质瘤LN229细胞的成球能力 [4]A novel isocitrate dehydrogenase 1 G131D mutation in glioblastoma. [5]胶质瘤术中超声表现与免疫组化分子标记物表达的相关性 [6]焦磷酸测序定量检测脑胶质瘤IDH1R132H突变 [7]A novel isocitrate dehydrogenase 1 G131D mutation in glioblastoma. [8]Methylation associated genes contribute to the favorable prognosis of gliomas with isocitrate dehydrogenase 1 mutation [9]异柠檬酸脱氢酶1基因突变焦磷酸测序检测方法的建立 [10]Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas