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Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Pan Yiming[1,2] * ; Li Yun[3,4] ; Chhetri Jagadish K[1,2,5] ; Liu Pan[1,2] ; Li Bowen[6] ; Liu Zuyun[7] ; Shui Guanghou[8] ; Ma Lina[9,10] ;
机构： [1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, 45 Changchun Street, Beijing, 100053, China. [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. [3]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, 45 Changchun Street, Beijing, 100053, China. [4]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. [5]Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. [6]LipidALL Technologies Company Limited, Changzhou, 213022, Jiangsu, China. [7]Center for Clinical Big Data and Analytics, Second Affiliated Hospital and Department of Big Data in Health Science, School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, China. [8]State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China. [9]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, 45 Changchun Street, Beijing, 100053, China. [10]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
出处：
DOI： 10.1007/s40520-023-02654-x
ISSN：

关键词： Functional decline Aging Intrinsic capacity Metabolomics

摘要：
Intrinsic capacity is the combination of individual physical and mental abilities, reflecting the aging degree of the older adults. However, the mechanisms and metabolic characteristics of the decline in intrinsic capacity are still unclear.To identify metabolic signatures and associated pathways of decline in intrinsic capacity based on the metabolite features.We recruited 70 participants aged 77.19 ± 8.31 years. The five domains of intrinsic capacity were assessed by Short Physical Performance Battery (for mobility), Montreal cognition assessment (for cognition), 30-Item Geriatric Depression Scale (for psychology), self-reported hearing/visual impairment (for sensory) and Nutritional risk screening (for vitality), respectively. The serum samples of participants were analyzed by liquid chromatography-mass spectrometry-based metabolomics, followed by metabolite set enrichment analysis and metabolic pathway analysis.There were 50 participants with a decline in intrinsic capacity in at least one of the domains. A total of 349 metabolites were identified from their serum samples. Overall, 24 differential metabolites, 5 metabolite sets and 13 pathways were associated with the decline in intrinsic capacity.Our results indicated that decline in intrinsic capacity had unique metabolomic profiles.The specific change of acyl carnitines was observed to be a feature of decline in intrinsic capacity. Dysregulation of the pentose phosphate pathway and of arginine and ornithine metabolism was strongly associated with the decline in intrinsic capacity.© 2024. The Author(s).

基金：
This work was supported by the National Key R&D Program of China (2020YFC2008606 and 2020YFC2008604) and National Natural Science Foundation of Beijing (7202059).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 4 区 老年医学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 老年医学
JCR分区：
出版当年[2022]版：
Q2 GERIATRICS & GERONTOLOGY
最新[2024]版：
Q2 GERIATRICS & GERONTOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, 45 Changchun Street, Beijing, 100053, China. [2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
通讯作者：
通讯机构： [3]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, 45 Changchun Street, Beijing, 100053, China. [4]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China. [9]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, 45 Changchun Street, Beijing, 100053, China. [10]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
推荐引用方式(GB/T 7714)：
Pan Yiming,Li Yun,Chhetri Jagadish K,et al.Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults[J].Aging Clinical And Experimental Research.2024,36(1):36.doi:10.1007/s40520-023-02654-x.
APA：
Pan Yiming,Li Yun,Chhetri Jagadish K,Liu Pan,Li Bowen...&Ma Lina.(2024).Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults.Aging Clinical And Experimental Research,36,(1)
MLA：
Pan Yiming,et al."Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults".Aging Clinical And Experimental Research 36..1(2024):36

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