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Value of neutrophil-to-lymphocyte ratio in neuronal intranuclear inclusion disease

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收录情况： ◇ SCIE

作者：
Du Nan[1,2] * ; Bao Lei[1,2] * ; Zhang Jing[3] * ; Li Xiaowen[1,2] ; Tian Jin[1,2] ; Xia Man[4] ; Chen Wei[5] ; Zhu Pinyi[6] ; Sun XiuJuan[7] ; Wang Min[8] ; Wu Yihan[9] ; He Lin[1,2] ; Gao Yang[10,11] ; Sun Wen[12] ; Zhang Zunsheng[1,2] ; Chen Hao[1,2,*1] ;
机构： [1]Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China. [2]Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China. [3]Department of Neurology, Xuanwu Hospital, Capital Medical University, Xicheng District, Beijing, 100053, China. [4]Department of Neurological Intensive Care, Yantai Yuhuangding Hospital, Yantai, 264000, China. [5]Department of Neurology,Tengzhou Central People's Hospital, Tengzhou, Shandong, 277500, China. [6]Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210029, China. [7]Department of Neurology, Liaocheng People's Hospital and Liaocheng Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, 252000, China. [8]Department of Neurology, The Second Hospital of Shandong University, Jinan, Shandong, 250033, China. [9]Department of Family Medicine, Inner Mongolia People's Hospital, Hohhot, 010057, China. [10]The Yancheng Clinical College of Xuzhou Medical University, No 166 Yulong Road, Yancheng, Jiangsu, 224000, China. [11]Department of Neurology, Yancheng City No.1 People's Hospital, No 166 Yulong Road, Yancheng, Jiangsu, 224000, China. [12]Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
出处：
DOI： 10.1016/j.heliyon.2024.e27953

关键词： Neuronal intranuclear inclusion disease Cognition Neuroinflammation

摘要：
The neutrophil-to-lymphocyte ratio (NLR) is a widely recognized marker of inflammation in peripheral blood. However, its specific role in neuronal intranuclear inclusion disease (NIID) has not been reported. This study aims to investigate the relationship between NIID and NLR.A multicenter database was collected, including 157 NIID patients from seven hospitals (The Affiliated Hospital of Xuzhou Medical University, Yantai Yuhuangding Hospital, Tengzhou Central People's Hospital,The Affiliated Brain Hospital of Nanjing Medical University, Liaocheng People's Hospital,The Second Hospital of Shandong University, Inner Mongolia People's Hospital, Xuanwu Hospital Capital Medical University,The First Affiliated Hospital of USTC), along with 157 age- and gender-matched healthy control subjects. White blood cell counts (including neutrophils, lymphocytes, monocytes, eosinophils, and basophils) were obtained, and the NLR was calculated. Additionally, cognitive impairment was assessed using clinical evaluation scores.NIID patients exhibited significantly higher NLR values compared to the healthy control group (p < 0.001). The plasma NLR levels in NIID patients showed a weak positive correlation with disease duration (r = 0.219, p = 0.016). However, no significant correlations were found between NLR and age of onset or cognitive impairment (p > 0.05).There is a significant association between NLR and NIID, suggesting a potential role of peripheral blood inflammation in the pathogenesis of NIID.© 2024 The Authors.

基金：
The work is funded by The opening Project of Provincial key Laboratory of Colleges and Universities in Jiangsu Province (XZSYSKF2020010); The Youth Medical Science and Technology Innovation Project of Xuzhou Municipal Health Commission (XWKYHT20200001); The Science and Technology Development Fund Project of the affiliated Hospital of Xuzhou Medical University in 2020 (XYFZ2020008).
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外文
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出版当年[2023]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
最新[2023]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
JCR分区：
出版当年[2022]版：
Q2 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China. [2]Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China. [2]Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China. [*1]Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China
推荐引用方式(GB/T 7714)：
Du Nan,Bao Lei,Zhang Jing,et al.Value of neutrophil-to-lymphocyte ratio in neuronal intranuclear inclusion disease[J].HELIYON.2024,10(6):e27953.doi:10.1016/j.heliyon.2024.e27953.
APA：
Du Nan,Bao Lei,Zhang Jing,Li Xiaowen,Tian Jin...&Chen Hao.(2024).Value of neutrophil-to-lymphocyte ratio in neuronal intranuclear inclusion disease.HELIYON,10,(6)
MLA：
Du Nan,et al."Value of neutrophil-to-lymphocyte ratio in neuronal intranuclear inclusion disease".HELIYON 10..6(2024):e27953

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