机构:[1]Capital Med Univ, Fu Xing Hosp, Dept Rehabil Ctr, Beijing, Peoples R China[2]Capital Med Univ, Clin Sch 8, Beijing, Peoples R China[3]Capital Med Univ, Xuan Wu Hosp, Dept Evidence Based Med, Beijing, Peoples R China首都医科大学宣武医院[4]Capital Med Univ, Xuan Wu Hosp, Dept Med Lib, Beijing, Peoples R China首都医科大学宣武医院
Background: The recovery of upper extremity motor impairment after stroke remains a challenging task. The clinical effectiveness of repetitive transcranial magnetic stimulation (rTMS), which is believed to aid in the recovery process, is still uncertain. Methods: A systematic search was conducted in Medline (Ovid), Cochrane and Embase electronic databases from March 28, 2014, to March 28, 2023. The inclusion criteria consisted of randomized controlled trials that assessed the effects of rTMS on the recovery of upper limb motor impairment among stroke patients. Various measurements, including the Fugl Meyer Assessment Upper Extremity Scale (FMA-UE), Brunnstrom recovery stage, Action Research Arm Test (ARAT), and Barthel index, were evaluated both before and after the intervention. Results: Nineteen articles with 865 patients were included. When considering only the rTMS parameters, both inhibitory and excitatory rTMS improved FMA-UE (MD = 1.87, 95% CI = [0.88]-[2.86], p < 0.001) and Barthel index (MD = 9.73, 95% CI = [4.57]-[14.89], p < 0.001). When considering only the severity of upper limb hemiplegia, both less severe (MD = 1.56, 95% CI = [0.64]-[2.49], p < 0.001) and severe (MD = 2.05, 95% CI = [1.09]-[3.00], p < 0.001) hemiplegia benefited from rTMS based on FMA-UE. However, when considering the rTMS parameters, severity of hemiplegia and stroke stages simultaneously, inhibitory rTMS was found to be significantly effective for less severe hemiplegia in the acute and subacute phases (MD = 4.55, 95% CI = [2.49]-[6.60], p < 0.001), but not in the chronic phase based on FMA-UE. For severe hemiplegia, inhibitory rTMS was not significantly effective in the acute and subacute phases, but significantly effective in the chronic phase (MD = 2.10, 95% CI = [0.75]-[3.45], p = 0.002) based on FMA-UE. Excitatory rTMS was found to be significantly effective for less severe hemiplegia in the acute and subacute phases (MD = 1.93, 95% CI = [0.58]-[3.28], p = 0.005) based on FMA-UE. The improvements in Brunnstrom recovery stage and ARAT need further research. Conclusion: The effectiveness of rTMS depends on its parameters, severity of hemiplegia, and stroke stages. It is important to consider all these factors together, as any single grouping method is incomplete.
基金:
This work was
supported by the Capital’s Funds for Health Improvement and
Research under grant no. 2022-4-7022.
第一作者机构:[1]Capital Med Univ, Fu Xing Hosp, Dept Rehabil Ctr, Beijing, Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Li Ran,Liu Sihan,Li Tianyuan,et al.The stratified effects of repetitive transcranial magnetic stimulation in upper limb motor impairment recovery after stroke: a meta-analysis[J].FRONTIERS IN NEUROLOGY.2024,15:doi:10.3389/fneur.2024.1369836.
APA:
Li, Ran,Liu, Sihan,Li, Tianyuan,Yang, Kun,Wang, Xue&Wang, Wenjiao.(2024).The stratified effects of repetitive transcranial magnetic stimulation in upper limb motor impairment recovery after stroke: a meta-analysis.FRONTIERS IN NEUROLOGY,15,
MLA:
Li, Ran,et al."The stratified effects of repetitive transcranial magnetic stimulation in upper limb motor impairment recovery after stroke: a meta-analysis".FRONTIERS IN NEUROLOGY 15.(2024)