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Association Between the Serum α-Klotho Level and Insulin Resistance in Adults: NHANES 2007-2016

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收录情况： ◇ SCIE

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机构： [1]Gannan Med Univ, Dept Clin Med 1, Ganzhou, JX, Peoples R China [2]Capital Med Univ, XuanWu Hosp, Dept Neurosurg, Beijing, Peoples R China [3]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Natl Clin Res Ctr Geriatr Dis, Dept Endocrinol, 28 Fuxing Rd, Beijing, Peoples R China

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关键词： Adults cross-sectional study insulin resistance klotho National Health and Nutrition Examination Survey

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ObjectiveThis study aimed to investigate the relationship between serum alpha-Klotho levels and insulin resistance (IR), a precursor to type 2 diabetes.MethodsThe study analyzed data from 4,758 adult participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016. The relationship between alpha-Klotho concentration and IR was assessed using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and odds ratios (OR) derived from logistic regression models.ResultsResults showed that every 1-ln increase in alpha-Klotho concentration raised the HOMA-IR value by 0.55 (95% confidence interval 0.35-0.74) and the odds of IR by 64% (odds ratio 1.64; 95% confidence interval 1.28-2.1). The odds of IR was 40% greater in highest tertile than in the lowest tertile.ConclusionThe findings of this study underscore a significant correlation between increased serum alpha-Klotho levels and the prevalence of IR.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区内分泌学与代谢

最新[2023]版：

大类 | 4 区医学

小类 | 4 区内分泌学与代谢

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出版当年[2022]版：

Q4 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q4 ENDOCRINOLOGY & METABOLISM

影响因子： 1.5 最新[2023版] 1.4 最新五年平均 2.1 出版当年[2022版] 1.9 出版当年五年平均 2.306 出版前一年[2021版] 1.5 出版后一年[2023版]

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第一作者机构： [1]Gannan Med Univ, Dept Clin Med 1, Ganzhou, JX, Peoples R China

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