机构:[1]Department of Vascular Surgery, Xuanwu Hospital and Institute of Vascular Surgery, Capital Medical University, Beijing, China外科系统血管外科首都医科大学宣武医院[2]Department of Intensive Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院
Purpose: The impact of carotid revascularization on cognitive function for patients with severe carotid artery stenosis remains uncertain. This study is aimed to investigate the 1-year neurocognitive outcomes of patients who accept carotid revascularization and identify the risk factors associated with postoperative cognitive decline. Methods: From April 2019 to April 2021, patients with >= 70% carotid artery stenosis who were treated with carotid endarterectomy (CEA) or carotid artery stenting (CAS) were recruited for this study. The Montreal Cognitive Assessment (MoCA) instrument was used to evaluate cognitive function preoperatively and at 3, 6, and 12 months postoperatively. Logistic regression analysis was built to identify potential risk factors for postoperative long-term cognitive decline. Results: A total of 89 patients who met the criteria were enrolled and completed 1-year follow-up. At 3, 6, and 12 months after carotid revascularization, the total MoCA score, attention, language fluency, and delayed recall score were significantly improved compared with the baseline scores (p<0.05). At 12 months, there was also a significant improvement in cube copying compared with baseline (p=0.034). Logistic regression analysis showed that the advancing age, left side, and symptomatic carotid artery stenosis were independent risk factors for cognitive deterioration at 12 months after surgery. Conclusions: Overall, carotid revascularization has a beneficial effect on cognition function in patients with severe carotid artery stenosis, while advancing age, left side, and symptomatic carotid artery stenosis were significantly related to a decreased cognitive score after carotid revascularization.
基金:
This study was supported by the National Key Research and Development Program of China (No.2021YFC2500500).
第一作者机构:[1]Department of Vascular Surgery, Xuanwu Hospital and Institute of Vascular Surgery, Capital Medical University, Beijing, China[2]Department of Intensive Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
共同第一作者:
通讯作者:
通讯机构:[1]Department of Vascular Surgery, Xuanwu Hospital and Institute of Vascular Surgery, Capital Medical University, Beijing, China[*1]Department of Vascular Surgery, Xuanwu Hospital and Institute of Vascular Surgery, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China
推荐引用方式(GB/T 7714):
Ning Yachan,Guo Julong,Pan Dikang,et al.The Effects of Carotid Revascularization on 1-Year Cognitive Performance in Patients With Carotid Artery Stenosis[J].JOURNAL OF ENDOVASCULAR THERAPY.2024,doi:10.1177/15266028241252007.
APA:
Ning, Yachan,Guo, Julong,Pan, Dikang,Wu, Sensen,Song, Lipo...&Gu, Yongquan.(2024).The Effects of Carotid Revascularization on 1-Year Cognitive Performance in Patients With Carotid Artery Stenosis.JOURNAL OF ENDOVASCULAR THERAPY,,
MLA:
Ning, Yachan,et al."The Effects of Carotid Revascularization on 1-Year Cognitive Performance in Patients With Carotid Artery Stenosis".JOURNAL OF ENDOVASCULAR THERAPY .(2024)