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Dimethyl Fumarate Modulates the Immune Environment and Improves Prognosis in the Acute Phase after Ischemic Stroke

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Bo Chunrui[1,2] * ; Li Jingkai[3] ; Wang Junjie[2,5] ; Zhang Yaxin[6] ; Wu Tao[2,5] ; Wang Mingyang[1,4,5] ; Hou Shiyue[1,4,5] ; Liang Yan[2,5] ; Zhang Xiyue[2,5] ; Zhao Shufang[2,5] ; Zhang Huixue[1] ; Wang Jianjian[1] ; Wang Lihua[1] ; Zhong Lianmei[2,5] ;
机构： [1]Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China [2]Department of Neurology, XuanWu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China [3]Department of Radiology, XuanWu Hospital, Capital Medical University, Beijing, China [4]Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China [5]Beijing Municipal Geriatric Medical Research Center, Beijing, China [6]Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, China
出处：
DOI： 10.1159/000539589
ISSN：

关键词： Dimethyl fumarate Ischemic stroke Infarct volume Immune cells Microglia Neuron

摘要：
Dimethyl fumarate (DMF) has shown potential for protection in various animal models of neurological diseases. However, the impact of DMF on changes in peripheral immune organs and the central nervous system (CNS) immune cell composition after ischemic stroke remains unclear.Eight-week-old C57BL/6J mice with photothrombosis ischemia and patients with acute ischemic stroke (AIS) were treated with DMF. TTC staining, flow cytometry, and immunofluorescence staining were used to evaluate the infarct volume and changes in immune cells in the periphery and the CNS.DMF reduced the infarct volume on day 1 after PT. DMF reduced the percentages of peripheral immune cells, such as neutrophils, dendritic cells, macrophages, and monocytes, on day 1, followed by NK cells on day 3 and B cells on day 7 after PT. In the CNS, DMF significantly reduced the percentage of monocytes in the brain on day 3 after PT. In addition, DMF increased the number of microglia in the peri-infarct area and reduced the number of neurons in the peri-infarct area in the acute and subacute phases after PT. In AIS patients, B cells decreased in patients receiving alteplase in combination with DMF.DMF can change the immune environment of the periphery and the CNS, reduce infarct volume in the acute phase, promote the recruitment of microglia and preserve neurons in the peri-infarct area after ischemic stroke.© 2024 The Author(s). Published by S. Karger AG, Basel.

基金：
This work was supported by National Natural Science Foundation (No. 82104435, Sponsor: Mingyang Wang, role: execution and analysis), National Natural Science Foundation (No. 82171396, Sponsor: Lihua Wang, role: study design), and the Major Science and Technology Special Project of Yunnan Province (No. 202102AA100061, Sponsor: Lianmei Zhong, role: manuscript conception, planning, writing, and decision to publish).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 内分泌学与代谢 4 区 免疫学 4 区 神经科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 内分泌学与代谢 4 区 免疫学 4 区 神经科学
JCR分区：
出版当年[2022]版：
Q4 ENDOCRINOLOGY & METABOLISM Q4 IMMUNOLOGY Q4 NEUROSCIENCES
最新[2023]版：
Q3 ENDOCRINOLOGY & METABOLISM Q3 NEUROSCIENCES Q4 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China [2]Department of Neurology, XuanWu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China
通讯作者：
通讯机构： [2]Department of Neurology, XuanWu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China [5]Beijing Municipal Geriatric Medical Research Center, Beijing, China
推荐引用方式(GB/T 7714)：
Bo Chunrui,Li Jingkai,Wang Junjie,et al.Dimethyl Fumarate Modulates the Immune Environment and Improves Prognosis in the Acute Phase after Ischemic Stroke[J].Neuroimmunomodulation.2024,31(1):126-141.doi:10.1159/000539589.
APA：
Bo Chunrui,Li Jingkai,Wang Junjie,Zhang Yaxin,Wu Tao...&Zhong Lianmei.(2024).Dimethyl Fumarate Modulates the Immune Environment and Improves Prognosis in the Acute Phase after Ischemic Stroke.Neuroimmunomodulation,31,(1)
MLA：
Bo Chunrui,et al."Dimethyl Fumarate Modulates the Immune Environment and Improves Prognosis in the Acute Phase after Ischemic Stroke".Neuroimmunomodulation 31..1(2024):126-141

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