Most nanoparticles are metabolized and accumulated in the liver; therefore, this review, based on most data collected from PubMed.gov between 2012 and 2023 with the keywords "nanomaterials induced hepatotoxicity," aims to elucidate the mechanism of nanoparticles leading to liver injury and propose relevant strategies. We discuss the biomedical approaches and strategies for mitigating liver injury, including 1) principle and recommendation of material selection; 2) nanoparticle surface modulation; 3) strategies inspired by virus and other biological phenomenon; and 4) drug and other possible adjunctive strategies. The optimal design of nanomaterials and therapeutic strategies to attenuate hepatotoxicity is critical for the development of nanomedicine.
基金：
Science and Technology Projects of Xiamen Municipal Bureau of Science and Technology [3502Z20194042, 2020J02063]; Open Research Fund of Key Laboratory of Nanomedical Technology of Fujian Medical University [2022KLNT201]; Science Foundation of Fujian Province [2022J01019]; Natural Science Foundation of Guangxi [2023GXNSFAA026023]; Central Government Guided Local Science and Technology Development Fund Projects [2023ZYZX1090]; National Natural Science Foundation of China [82360360, 8200011769]
第一作者机构：[3]Xiamen Univ, Inst Neurosci, Med Coll, Fujian Prov Key Lab Neurodegenerat Dis & Aging Res, Xiamen 361102, Peoples R China[4]Xiamen Univ, Affiliated Hosp 1, Xiamen 361005, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Xiamen Univ, Inst Chest & Lung Dis, Xiamen 361101, Peoples R China[2]Fujian Med Univ, Nanomed Technol Res Inst, Sch Pharm, Key Lab Nanomed Technol,Educ Dept Fujian Prov, Fuzhou 350122, Peoples R China[3]Xiamen Univ, Inst Neurosci, Med Coll, Fujian Prov Key Lab Neurodegenerat Dis & Aging Res, Xiamen 361102, Peoples R China[4]Xiamen Univ, Affiliated Hosp 1, Xiamen 361005, Peoples R China
推荐引用方式(GB/T 7714)：
Gao Chengtian,Wang Mingdong,Zheng Yali,et al.Hepatotoxicity of nanomaterials: From mechanism to therapeutic strategy[J].NANOTECHNOLOGY REVIEWS.2024,13(1):doi:10.1515/ntrev-2024-0074.
APA：
Gao, Chengtian,Wang, Mingdong,Zheng, Yali,Zhang, Liang,He, Jiawei...&Wang, Zhanxiang.(2024).Hepatotoxicity of nanomaterials: From mechanism to therapeutic strategy.NANOTECHNOLOGY REVIEWS,13,(1)
MLA：
Gao, Chengtian,et al."Hepatotoxicity of nanomaterials: From mechanism to therapeutic strategy".NANOTECHNOLOGY REVIEWS 13..1(2024)
