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Protective effects of oxymatrine against arsenic trioxideinduced liver injury

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机构： [1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Department of Anatomy & Histology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China [3]Department of Anesthesiology, the First Affiliated Hospital of Xinxiang Medical University, Henan, China [4]Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China

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关键词： oxymatrine arsenic trioxide liver HO-1 Nrf-2

摘要：

Oxymatrine, a quinolizidine natural drug extracted from Sophora japonica, has been reported to have neuroprotective effect and cardioprotective effect. However, the protective effect of oxymatrine on arsenic trioxide (As2O3)-induced liver injury has not been reported. In the present study, we investigated the protective effects of oxymatrine on As2O3-induced liver injury in rats. Male Wistar rats were administrated 3mg/kg As2O3 intravenous injection on alternate days for 4 days. Oxymatrine was given 1 h before As2O3 treatment. The results showed that oxymatrine inhibited As2O3-induced hepatic pathological damage, liver ROS level and MDA level in a dosedependent manner. As2O3 decreased the antioxidant enzymes SOD, GPX, and CAT activity and the decrease was inhibited by treatment of oxymatrine. Furthermore, oxymatrine attenuated the retention of arsenic in liver tissues and improved the expression of Nrf2 and HO-1. In conclusion, our results suggested that oxymatrine protected against As2O3-induced oxidative damage by activating Nrf2/HO-1 signaling pathway.

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出版当年[2016]版：

大类 | 1 区

医学

小类 | 2 区细胞生物学 2 区肿瘤学

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无

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出版当年[2015]版：

Q1 CELL BIOLOGY Q1 ONCOLOGY

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无

影响因子： 0 最新[2023版] 0 最新五年平均 5.008 出版当年[2015版] 5.415 出版当年五年平均 6.359 出版前一年[2014版] 5.168 出版后一年[2016版]

第一作者：

第一作者机构： [1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China

通讯作者：

通讯机构： [1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China [4]Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China

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