机构：[1]First Hospital of Harbin Medical University, China[2]Xuanwu Hospital of Capital Medical University, China首都医科大学宣武医院[3]Mu Danjiang Medical College[4]Biochemistry & Molecular Biology Department, University of Georgia, USA
We studied the effects of varying and steady-state concentrations of arsenic trioxide (As2O3) On apoptosis and differentiation of several cell fines in vitro. We also studied the same effects of fluctuating vs constant concentrations of As2O3 in Vivo in patients treated with daily 3-hour fast infusions or daily slow, continuous infusions. Intracellular concentrations of arsenic and apoptosis rate were higher whereas differentiation was reduced in cells exposed to constant concentrations of As2O3.
基金：
this research received financial assistance from the
National Natural Science Foundation (approval number:
30370507) and Hei longjiang Excellent Youth Foundation
(approval number: 2003AA9CS188-12).
第一作者机构：[1]First Hospital of Harbin Medical University, China[*1]The First Hospital of Harbin Medical University, Harbin, China
通讯作者：
通讯机构：[*1]The First Hospital of Harbin Medical University, Harbin, China
推荐引用方式(GB/T 7714)：
Jin Zhou,Ran Meng,Xinhua Sui,et al.Effects of administration styles of arsenic trioxide on intracellular arsenic concentration, cell differentiation and apoptosis[J].HAEMATOLOGICA.2005,90(9):1277.
APA：
Jin Zhou,Ran Meng,Xinhua Sui,Lu Meng,Jianping Jia&Baofeng Yang.(2005).Effects of administration styles of arsenic trioxide on intracellular arsenic concentration, cell differentiation and apoptosis.HAEMATOLOGICA,90,(9)
MLA：
Jin Zhou,et al."Effects of administration styles of arsenic trioxide on intracellular arsenic concentration, cell differentiation and apoptosis".HAEMATOLOGICA 90..9(2005):1277
医学