机构：[1]Department of Pharmacy, Xuanwu Hospital, Capital Medical University, Beijing, China,首都医科大学宣武医院[2]Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA,[3]College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA,[4]Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA, and[5]Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
Background. Patients with coronavirus disease 2019 (COVID-19) often experience persistent symptoms, known as postacute sequelae of COVID-19 or long COVID, after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Chronic lung disease (CLD) has been identified in small-scale studies as a potential risk factor for long COVID. Methods. This large-scale retrospective cohort study using the National COVID Cohort Collaborative data evaluated the link between CLD and long COVID over 6 months after acute SARS-CoV-2 infection. We included adults (aged >= 18 years) who tested positive for SARS-CoV-2 during any of 3 SARS-CoV-2 variant periods and used logistic regression to determine the association, considering a comprehensive list of potential confounding factors, including demographics, comorbidities, socioeconomic conditions, geographical influences, and medication. Results. Of 1 206 021 patients, 1.2% were diagnosed with long COVID. A significant association was found between preexisting CLD and long COVID (adjusted odds ratio [aOR], 1.36). Preexisting obesity and depression were also associated with increased long COVID risk (aOR, 1.32 for obesity and 1.29 for depression) as well as demographic factors including female sex (aOR, 1.09) and older age (aOR, 1.79 for age group 40-65 [vs 18-39] years and 1.56 for >65 [vs 18-39] years). Conclusions. CLD is associated with higher odds of developing long COVID within 6 months after acute SARS-CoV-2 infection. These data have implications for identifying high-risk patients and developing interventions for long COVID in patients with CLD.
基金：
NCATS [U24 TR002306, NCATS-P00438-B]; National Institute of General Medical Sciences [U54 GM115458, U54GM10494]
第一作者机构：[1]Department of Pharmacy, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska, USA,[3]College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Xiaotong,Anzalone Alfred Jerrod,Dai Daisy,et al.Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study[J].OPEN FORUM INFECTIOUS DISEASES.2024,11(8):doi:10.1093/ofid/ofae424.
APA：
Zhang, Xiaotong,Anzalone, Alfred Jerrod,Dai, Daisy,Cochran, Gary,Dai, Ran&Rupp, Mark E..(2024).Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study.OPEN FORUM INFECTIOUS DISEASES,11,(8)
MLA：
Zhang, Xiaotong,et al."Chronic Lung Disease as a Risk Factor for Long COVID in Patients Diagnosed With Coronavirus Disease 2019: A Retrospective Cohort Study".OPEN FORUM INFECTIOUS DISEASES 11..8(2024)
