机构:[1]Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan[2]Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan[3]Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan[4]Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan[5]School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan[6]Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand[7]Department of Medicine, Division of Neurology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand[8]Institute for Neurosciences, St. Luke’s Medical Center, Quezon City, Philippines[9]Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, , Hong Kong, China[10]Geriatric Behavioral Neurology Project, New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan[11]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China神经科系统神经内科首都医科大学宣武医院[12]Department of Neurology, The Catholic University of Korea, Eunpyeong St. Mary’s Hospital, Seoul, Korea m Neurology Department, Faculty of Medicine Universitas Indonesia[13]Dr. Cipto Mangunkusumo National Central General Hospital Indonesia[14]Universitas Indonesia General Hospital[15]Memory Clinic, Siloam Hospitals Lippo Village, Faculty of Medicine, Universitas Pelita Harapan, Banten, Indonesia[16]Nuclear Medicine Laboratory, Division of Short-lived Radioisotope Research, Research Center for Accelerator and Radioisotope Science (RARIS), Tohoku University, Sendai, Japan
Background: The number of patients with Alzheimer's disease (AD) has increased dramatically in Asia. Objective: To update the demographic characteristics of patients with AD and their informants in eight Asian countries and compare them from 12 years prior. Methods: The A1-A3 components of the Uniform Dataset (UDS), version 3.0, were administered in Taiwan, Beijing, Hong Kong, Korea, Japan, Philippines, Thailand, and Indonesia. Data were compared with patients with AD in the first registration using the UDS version 1.0 from 2010-2014 in the same regions. Results: A total of 1885 patients with AD and their informants were recruited from 2022 to 2024 and were compared with 2042 patients recruited a decade prior. Each country had its own unique characteristics that changed between both eras. The mean age of the patients and informants was 79.8 +/- 8.2 years and 56.5 +/- 12.1 years, respectively. Compared with the first registration, the patients were older (79.8 vs 79.0, p=0.002) and had worse global function (mean CDR-SB scores 6.1 vs 5.8, p<0.001); more informants were children (56 % vs. 48 %, p<0.001), and their frequency of in-person visits increased significantly if not living together. A total of 11 %, 4.5 %, 11 %, and 0.4 % of the patients had a reported history of cognitive impairment in their mothers, fathers, siblings, and children, respectively; all percentages, except children, increased significantly over the past decade. Conclusion: The present study reports the heterogeneous characteristics of patients with AD and their informants in Asian countries, and the distinct changes in the past decade. The differences in dementia evaluation and care between developing and developed countries warrant further investigation.
基金:
National Health Research Institutes [NHRI-11A1-CG-CO-06-2225-1, NHRI-12A1-CG-CO-06-2225-1, NHRI-13A1-CG-CO-06-2225-1]; Kaohsiung Medical University Research Center [KMU-TC112B02]
第一作者机构:[1]Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan
通讯作者:
通讯机构:[2]Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan[3]Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan[4]Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan[5]School of Post-Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan[*1]Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, 100,Sect 1,Tzyou Rd, Kaohsiung, Taiwan
推荐引用方式(GB/T 7714):
Jhang Kai-Ming,Dharmasaroja Pornpatr A.,Senanarong Vorapun,et al.A 12-year comparison of patients with Alzheimer's ' s dementia with their informants in eight Asian countries[J].ASIAN JOURNAL OF PSYCHIATRY.2024,101:doi:10.1016/j.ajp.2024.104204.
APA:
Jhang, Kai-Ming,Dharmasaroja, Pornpatr A.,Senanarong, Vorapun,Dominguez, Jacqueline,Lam, Linda C. W....&Yang, Yuan-Han.(2024).A 12-year comparison of patients with Alzheimer's ' s dementia with their informants in eight Asian countries.ASIAN JOURNAL OF PSYCHIATRY,101,
MLA:
Jhang, Kai-Ming,et al."A 12-year comparison of patients with Alzheimer's ' s dementia with their informants in eight Asian countries".ASIAN JOURNAL OF PSYCHIATRY 101.(2024)