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Melatonin Ameliorates Abnormal Sleep-Wake Behavior via Facilitating Lipid Metabolism in a Zebrafish Model of Parkinson's Disease

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：重点期刊

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机构： [1]Department of Neurology and Clinical Research Center of Neurological Disease, The Second Afliated Hospital of Soochow University, Suzhou 215004, China [2]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou 215123, China [3]Department of Neurology, The Fourth Afliated Hospital of Soochow University, Suzhou 215000, China [4]Center for Circadian Clocks, Soochow University, Suzhou 215123, China [5]School of Biology & Basic Medical Sciences, Medical College, Soochow University, Suzhou 215123, China [6]Department of Neurology, Xiongan Xuanwu Hospital, Xiongan 071700, China

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关键词： Zebrafish Melatonin Melatonin receptor 1 Parkinson's disease Sleep-wake disorder Lipid metabolism

摘要：

Sleep-wake disorder is one of the most common nonmotor symptoms of Parkinson's disease (PD). Melatonin has the potential to improve sleep-wake disorder, but its mechanism of action is still unclear. Our data showed that melatonin only improved the motor and sleep-wake behavior of a zebrafish PD model when melatonin receptor 1 was present. Thus, we explored the underlying mechanisms by applying a rotenone model. After the PD zebrafish model was induced by 10 nmol/L rotenone, the motor and sleep-wake behavior were assessed. In situ hybridization and real-time quantitative PCR were used to detect the expression of melatonin receptors and lipid-metabolism-related genes. In the PD model, we found abnormal lipid metabolism, which was reversed by melatonin. This may be one of the main pathways for improving PD sleep-wake disorder.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 3 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区神经科学

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Q1 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 5.9 最新[2023版] 5.4 最新五年平均 5.6 出版当年[2022版] 5.4 出版当年五年平均 5.271 出版前一年[2021版] 5.9 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Neurology and Clinical Research Center of Neurological Disease, The Second Afliated Hospital of Soochow University, Suzhou 215004, China [2]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou 215123, China

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通讯作者：

通讯机构： [1]Department of Neurology and Clinical Research Center of Neurological Disease, The Second Afliated Hospital of Soochow University, Suzhou 215004, China [2]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institutes of Neuroscience, Soochow University, Suzhou 215123, China [6]Department of Neurology, Xiongan Xuanwu Hospital, Xiongan 071700, China

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