Resting-state functional magnetic resonance imaging (rs-fMRI) has been widely used in the identification of mild cognitive impairment (MCI) research, MCI patients are relatively at a higher risk of progression to Alzheimer's disease (AD). However, almost machine learning and deep learning methods are rarely analyzed from the perspective of spatial structure and temporal dimension. In order to make full use of rs-fMRI data, this study constructed a dynamic spatiotemporal graph neural network model, which mainly includes three modules: temporal block, spatial block, and graph pooling block. Our proposed model can extract the BOLD signal of the subject's fMRI data and the spatial structure of functional connections between different brain regions, and improve the decision-making results of the model. In the study of AD, MCI and NC, the classification accuracy reached 83.78% outperforming previously reported, which manifested that our model could effectively learn spatiotemporal, and dynamic spatio-temporal method plays an important role in identifying different groups of subjects. In summary, this paper proposed an end-to-end dynamic spatio-temporal graph neural network model, which uses the information of the temporal dimension and spatial structure in rs-fMRI data, and achieves the improvement of the three classification performance among AD, MCI and NC.
基金:
National Key Research and Development Program of China [2022YFF1202400]; National Natural Science Foundation of China [62276181, 82020108013]; Tianjin Science and Technology Program [20JCZDJC00620]
第一作者机构:[1]Tianjin Univ, Acad Med Engn & Translat Med, Tianjin 300072, Peoples R China
通讯作者:
通讯机构:[2]Hainan Univ, Sch Biomed Engn, Haikou 570228, Peoples R China[3]Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China[4]Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100069, Peoples R China[5]Natl Clin Res Ctr Geriatr Dis, Beijing 100053, Peoples R China[6]Shenzhen Bay Lab, Inst Biomed Engn, Shenzhen 518118, Peoples R China
推荐引用方式(GB/T 7714):
An Xingwei,Zhou Yutao,Di Yang,et al.A Novel Method to Identify Mild Cognitive Impairment Using Dynamic Spatio-Temporal Graph Neural Network[J].IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING.2024,32:3328-3337.doi:10.1109/TNSRE.2024.3450443.
APA:
An, Xingwei,Zhou, Yutao,Di, Yang,Han, Ying&Ming, Dong.(2024).A Novel Method to Identify Mild Cognitive Impairment Using Dynamic Spatio-Temporal Graph Neural Network.IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING,32,
MLA:
An, Xingwei,et al."A Novel Method to Identify Mild Cognitive Impairment Using Dynamic Spatio-Temporal Graph Neural Network".IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 32.(2024):3328-3337