机构：[a]Medical School of Southeast University, Nanjing, China[b]Department of Neurology, affiliated ZhongDa Hospital of Southeast University, and The Institute of Neuropsychiatry of Southeast University, Nanjing, China[c]Department of Neurology, XuanWu Hospital, The Capital University of Medical Sciences, Beijing, China神经内科首都医科大学宣武医院
Introduction: Impaired capacity for self-reference has been observed in amnestic mild cognitive impairment (aMCI) subjects who are thought to be the likely to develop into clinical Alzheimer's disease (AD). The altered pattern of self-referencing network (SRN) is not yet well understood in aMCI subjects particularly in resting state, and little is known about the relationship between SRN and other resting-state networks in aMCI subjects. Methods: The study was designed to administer longitudinal resting-state functional magnetic resonance imaging (fMRI) scanning to 26 aMCI subjects and 18 matched healthy controls. Independent component analysis was used to separate SRN, and a further crosscorrelation approach was recruited to explore the relationship between SRN and other resting-state networks. Results: Compared to controls, selective changes of SRN regarding to the increased functional connectivity between ventromedial prefrontal cortex/medial orbital prefrontal cortex/gyrus rectus and the mean time series of SRN at baseline in aMCI, while these functional connections were associated with more extent of longitudinal diminish after follow up in the same subjects. In addition, greater decreased connectivity relationship between SRN and default mode network was observed in aMCI subjects. Conclusions: Altered patterns of resting-state SRN were firstly explored in aMCI subjects, and it could help guide subsequent investigations designed to specify the precise functional implications of SRN in the progression of aMCI. Crown Copyright (C) 2011 Published by Elsevier Srl. All rights reserved.
基金：
National Natural Science Foundation of China(No. 30825014; No. 30971016; No. 30970814)
National Basic Research Program of China (973 Program) (No. 2007CB512308)
National Hi-Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413)
National Key Technologies R&D Program
During the 11th Five-year Plan Period-Intervention and Control on Ageing Related Disease (Diagnosis and Treatment of Mild Cognitive Impairment) (No. 2006BAI02B01)
第一作者机构：[a]Medical School of Southeast University, Nanjing, China[b]Department of Neurology, affiliated ZhongDa Hospital of Southeast University, and The Institute of Neuropsychiatry of Southeast University, Nanjing, China
通讯作者：
通讯机构：[c]Department of Neurology, XuanWu Hospital, The Capital University of Medical Sciences, Beijing, China[*1]Department of Neurology, affiliated ZhongDa Hospital of Southeast University, and The Institute of Neuropsychiatry of Southeast University, Nanjing, China.
推荐引用方式(GB/T 7714)：
Feng Bai,Yongmei Shi,Yonggui Yuan,et al.Altered self-referential network in resting-state amnestic type mild cognitive impairment[J].CORTEX.2012,48(5):604-613.doi:10.1016/j.cortex.2011.02.011.
APA：
Feng Bai,Yongmei Shi,Yonggui Yuan,Yi Wang,Chunxian Yue...&Zhijun Zhang.(2012).Altered self-referential network in resting-state amnestic type mild cognitive impairment.CORTEX,48,(5)
MLA：
Feng Bai,et al."Altered self-referential network in resting-state amnestic type mild cognitive impairment".CORTEX 48..5(2012):604-613
心理学