机构：[a]School of Clinical Medicine, Southeast University, Nanjing, China[b]Department of Neurology, affiliated ZhongDa Hospital of Southeast University, and The Institute of Neuropsychiatry of Southeast University, Nanjing, China[c]Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China[d]Computational Neuroscience, University of Ulster, Magee Campus, Derry, Northern Ireland, UK[e]Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA[f]Department of Neurology, XuanWu Hospital, The Capital University of Medical Sciences, Beijing, China神经内科首都医科大学宣武医院
The cerebellum is known to be a relatively well preserved structure, but subtle alterations may occur early in the evolution of Alzheimer's disease (AD). Amnestic mild cognitive impairment (aMCI) patients appear to be particularly vulnerable to AD. However, little is currently known whether altered patterns of cerebellar function occur in aMCI patients. 26 aMCI patients and 18 well-matched healthy controls underwent a baseline resting-state functional magnetic resonance imaging (fMRI) scan. After a mean follow-up period of 20 months, the subjects who successfully completed baseline fMRI scans underwent a further follow-up scan, while spontaneous activation and functional connectivity of the cerebellum were explored by using resting-state fMRI. Compared to controls, increased amplitude of low frequency fluctuation of the posterior cerebellar lobe may contribute to the underlying mechanisms affected, while greater decreased functional connections to the posterior cerebellar lobe were identified in the longitudinal study of aMCI patients. This suggests that abnormal functional connectivity of the cerebellum may offer a more sensitive and possibly preferred index of functional disturbance than regional activity measures in aMCI patients. The cerebellum may be partly related to the underlying mechanisms of aMCI, and it could help guide subsequent investigations designed to specify the precise functional role of cerebellum in aMCI patients.
基金：
National Natural Science Foundation of China (No. 30825014; No. 30971016), National Basic Research Program of China (973 Program) (No. 2007CB512308),
National Hi- Tech Research and Development Program of China (863 Program) (No. 2008AA02Z413),
National Key Technologies R&D Program During the 11th Fiveyear Plan Period-Intervention and
Control on Ageing Related Disease (Diagnosis and Treatment of Mild Cognitive Impairment) (No. 2006BAI02B01) and
The Scientific Research of Foundation of Graduate of School of Southeast University (YBJJ0824).
第一作者机构：[a]School of Clinical Medicine, Southeast University, Nanjing, China[b]Department of Neurology, affiliated ZhongDa Hospital of Southeast University, and The Institute of Neuropsychiatry of Southeast University, Nanjing, China
通讯作者：
通讯机构：[*1]Department of Neurology, affiliated ZhongDa Hospital of Southeast University, and The Institute of Neuropsychiatry of Southeast University, Nanjing 210009, China[*2]Neurology Department, XuanWu Hospital, The Capital University of Medical Sciences, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Feng Bai,Wei Liao,David R. Watson,et al.Mapping the Altered Patterns of Cerebellar Resting-State Function in Longitudinal Amnestic Mild Cognitive Impairment Patients[J].JOURNAL OF ALZHEIMERS DISEASE.2011,23(1):87-99.doi:10.3233/JAD-2010-101533.
APA：
Feng Bai,Wei Liao,David R. Watson,Yongmei Shi,Yonggui Yuan...&Zhijun Zhang.(2011).Mapping the Altered Patterns of Cerebellar Resting-State Function in Longitudinal Amnestic Mild Cognitive Impairment Patients.JOURNAL OF ALZHEIMERS DISEASE,23,(1)
MLA：
Feng Bai,et al."Mapping the Altered Patterns of Cerebellar Resting-State Function in Longitudinal Amnestic Mild Cognitive Impairment Patients".JOURNAL OF ALZHEIMERS DISEASE 23..1(2011):87-99
