机构：[a]Department of Radiology, China-Japan Friendship Hospital, Beijing, 100029,China[b]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[c]Department of Medical Imaging, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405, China影像专科广东省中医院[d]State Key Laboratory of Cognitive Neuroscience and Learning & IDG/Mc Govern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China[e]Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China
Objective: In previous studies, post-stroke depression (PSD) was found to be related to stroke characteristics as well as social and psychological factors. This study identified altered functional connectivity (FC) in patients with PSD at the subacute phase in three brain networks: default mood network (DMN), cognitive control network (CCN), and affective network (AN). The correlation between FC and the severity of PSD was investigated. Materials and methods: Resting-state functional magnetic resonance image (rs-fMRI) was performed on 26 PSD patients (6 females), 24 stroke patients without depression (5 females), and 24 age-matched normal controls (6 females) all aged 40-75 years. The FC values of DMN, CCN, and AN were calculated and compared among the three groups. The Hamilton Depression Rating Scale (HDRS) (17 items) was employed and the score was correlated with FC in the PSD group. Results: The FCs of the three networks were altered in PSD patients at the subacute phase compared to stroke patients without depression and normal controls (NC). Moreover, the left inferior parietal gyrus, the left orbital part of inferior frontal gyrus, and left angular gyrus (which indicated altered FC) were significantly correlated with HDRS scores in PSD patients. Conclusions: Alteration of the three neural networks might be correlated with the development of PSD at the subacute phase of stroke.
第一作者机构：[a]Department of Radiology, China-Japan Friendship Hospital, Beijing, 100029,China
通讯作者：
通讯机构：[b]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China[d]State Key Laboratory of Cognitive Neuroscience and Learning & IDG/Mc Govern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China[e]Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, 100875, China[*1]Department of Neuroimaging, Beijing Tiantan Hospital, Capital Medical University, No.6 Tiantanxili, Dongcheng District, Beijing, 100050, China.[*2]State Key Laboratory of Cognitive Neuroscience and Learning & IDG/Mc Govern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
推荐引用方式(GB/T 7714)：
Peiyao Zhang,Jing Wang,Qin Xu,et al.Altered functional connectivity in post-ischemic stroke depression: A resting-state functional magnetic resonance imaging study[J].EUROPEAN JOURNAL OF RADIOLOGY.2018,100:156-165.doi:10.1016/j.ejrad.2018.01.003.
APA：
Peiyao Zhang,Jing Wang,Qin Xu,Zheng Song,Jianping Dai&Jun Wang.(2018).Altered functional connectivity in post-ischemic stroke depression: A resting-state functional magnetic resonance imaging study.EUROPEAN JOURNAL OF RADIOLOGY,100,
MLA：
Peiyao Zhang,et al."Altered functional connectivity in post-ischemic stroke depression: A resting-state functional magnetic resonance imaging study".EUROPEAN JOURNAL OF RADIOLOGY 100.(2018):156-165
