机构：[1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China,神经内科首都医科大学宣武医院[2]Department of Imaging & Imaging Institute of Rehabilitation and Development of Brain Function, The Second Clinical Institute of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, China,[3]Beijing Institute of Geriatrics, Beijing, China,[4]National Clinical Research Center for Geriatric Disorders, Beijing, China,[5]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China
The rapidly increasing number of patients with Alzheimer's disease (AD) worldwide has become a major public concern. Mild cognitive impairment (MCI), characterized with accelerated memory decline than normal aging, is a stage between cognitively unimpaired and dementia. Identification of MCI in the Alzheimer's continuum from normal aging, is important for early diagnosis and improved intervention of AD. The imaging technique has been extensively used for diagnose and understanding the mechanisms of MCI. Firstly, we review the recent progresses in the research framework of MCI depending on the clinical and/or biomarker findings. Secondly, we cover studies that use of rs-fMRI (resting state functional magnetic resonance imaging) for the brain activities and functional connectivity between normal aging and MCI. Other methodologies and multi-modal studies for investigating the mechanism and early diagnosis of MCI are also discussed. Finally, we discuss how genetic and environmental factors such as education could interact with in MCI. Overall, MCI is a heterogeneous state and employing resting state neuroimaging with other AD biomarker approaches will be able to target in the more precise population and AD-related pathology process.
基金：
This article was supported by The National Key Research and
Development Program of China (2016YFC1306300), National
Natural Science Foundation of China (Grant 61633018),
Beijing Municipal Commission of Health and Family Planning
(PXM2018_026283_000002).
第一作者机构：[1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China,[2]Department of Imaging & Imaging Institute of Rehabilitation and Development of Brain Function, The Second Clinical Institute of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, China,[3]Beijing Institute of Geriatrics, Beijing, China,[4]National Clinical Research Center for Geriatric Disorders, Beijing, China,[5]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Lin Li,Xing Guoqiang,Han Ying.Advances in Resting State Neuroimaging of Mild Cognitive Impairment[J].FRONTIERS IN PSYCHIATRY.2018,9:doi:10.3389/fpsyt.2018.00671.
APA：
Lin, Li,Xing, Guoqiang&Han, Ying.(2018).Advances in Resting State Neuroimaging of Mild Cognitive Impairment.FRONTIERS IN PSYCHIATRY,9,
MLA：
Lin, Li,et al."Advances in Resting State Neuroimaging of Mild Cognitive Impairment".FRONTIERS IN PSYCHIATRY 9.(2018)
