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Neuroprotection on ischemic brain injury by Mg2+/H2 released from endovascular Mg implant

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ CSCD-C ◇ 卓越：高起点新刊

作者：
Zhang Yang[1,2] * ; Zhang Hongkang[3] * ; Jiang Miaowen[4] * ; Cao Xiaofeng[3] ; Ge Xiaoxiao[4] ; Song Baoying[1,2] ; Lan Jing[4] ; Zhou Wenhao[5] ; Qi Zhengfei[4] ; Gu Xuenan[6] ; Liu Juzhe[7] ; Zheng Yufeng[3] ; Li Ming[1,2] ; Ji Xunming[1,2,4] ;
机构： [1]Department of Neurology and Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [2]China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [3]School of Materials Science and Engineering, Peking University, Beijing, 100871, China [4]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China [5]Biomaterials Research Center, Northwest Institute for Non-ferrous Metal Research, Xi’an, 710016, China [6]School of Bioengineering, Beihang University, Beijing, 100191, China [7]The Key Laboratory of Resources and Environmental System Optimization, Ministry of Education, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 100096, China
出处：
DOI： 10.1016/j.bioactmat.2024.08.019

关键词： Magnesium Acute ischemic stroke Neuroprotection Biodegradable implantation Hydrogen

摘要：
Most acute ischemic stroke patients with large vessel occlusion require stent implantation for complete recanalization. Yet, due to ischemia-reperfusion injury, over half of these patients still experience poor prognoses. Thus, neuroprotective treatment is imperative to alleviate the ischemic brain injury, and a proof-of-concept study was conducted on "biodegradable neuroprotective stent". This concept is premised on the hypothesis that locally released Mg2+/H2 from Mg metal within the bloodstream could offer synergistic neuroprotection against reperfusion injury in distant cerebral ischemic tissues. Initially, the study evaluated pure Mg's neuroactive potential using oxygen-glucose deprivation/reoxygenation (OGD/R) injured neuron cells. Subsequently, a pure Mg wire was implanted into the common carotid artery of the transient middle cerebral artery occlusion (MCAO) rat model to simulate human brain ischemia/reperfusion injury. In vitro analyses revealed that pure Mg extract aided mouse hippocampal neuronal cell (HT-22) in defending against OGD/R injury. Additionally, the protective effects of the Mg wire on behavioral abnormalities, neural injury, blood-brain barrier disruption, and cerebral blood flow reduction in MCAO rats were verified. Conclusively, Mg-based biodegradable neuroprotective implants could serve as an effective local Mg2+/H2 delivery system for treating distant cerebral ischemic diseases.© 2024 The Authors.

基金：
This study was funded by National Natural Science Foundation of China (82027802, 82102220), Research Funding on Translational Medicine from Beijing Municipal Science and Technology Commission (Z221100007422023), Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support (YGLX202325), Non-profit Central Research Institute Fund of Chinese Academy of Medical (2023- JKCS-09), Beijing Association for Science and Technology Youth Talent Support Program (BYESS2022081), Science and Technology Innovation Service Capacity Building Project of Beijing Municipal Education Commission (11000023T000002157177), Outstanding Young Talents Program of Capital Medical University (B2305), Beijing Municipal Natural Science Foundation (7244510), Beijing Nova Program (20230484286).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
JCR分区：
出版当年[2022]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Neurology and Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [2]China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurology and Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [2]China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [4]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China
推荐引用方式(GB/T 7714)：
Zhang Yang,Zhang Hongkang,Jiang Miaowen,et al.Neuroprotection on ischemic brain injury by Mg2+/H2 released from endovascular Mg implant[J].Bioactive Materials.2024,42:124-139.doi:10.1016/j.bioactmat.2024.08.019.
APA：
Zhang Yang,Zhang Hongkang,Jiang Miaowen,Cao Xiaofeng,Ge Xiaoxiao...&Ji Xunming.(2024).Neuroprotection on ischemic brain injury by Mg2+/H2 released from endovascular Mg implant.Bioactive Materials,42,
MLA：
Zhang Yang,et al."Neuroprotection on ischemic brain injury by Mg2+/H2 released from endovascular Mg implant".Bioactive Materials 42.(2024):124-139

相关文献

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