机构：[a]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University,[b]Department of Epidemiology, School of Public Health, Medical College of Soochow University,[c]Department of Neurology, The Affiliated Wujiang Hospital of Nantong University,[d]Department of Neurology, Suzhou Hospital Affiliated to Nanjing Medical University,[e]Department of Neurology, The First Affiliated Hospital of Soochow University,[f]Institutes of Neuroscience, Soochow University, Suzhou ,China[g]The George Institute for Global Health, Royal Prince Alfred Hospital, Sydney, NSW , Australia
Background: Low magnesium levels are associated with an elevated risk of stroke. In this study, we investigated the association between magnesium levels on hospital admission and in-hospital mortality in acute ischemic stroke (AIS) patients. Methods: A total of 2,485 AIS patients, enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city, were included in this study. The patients were divided into 4 groups according to their level of admission magnesium: Q1 (< 0.82 mmol/L), Q2 (0.82-0.89 mmol/L), Q3 (0.89-0.98 mmol/L), and Q4 (>= 0.98 mmol/L). Cox proportional hazard model was used to estimate the effect of magnesium on all-cause in-hospital mortality in AIS patients. Results: During hospitalization, 92 patients (3.7%) died from all causes. The lowest serum magnesium level (Q1) was associated with a 2.66-fold increase in the risk of in-hospital mortality in comparison to Q4 (hazard ratio [HR] 2.66; 95% CI 1.55-4.56; p-trend < 0.001). After adjusting for age, sex, time from onset to hospital admission, baseline National Institutes of Health Stroke Scale score, and other potential covariates, HR for Q1 was 2.03 (95% CI 1.11- 3.70; p-trend = 0.014). Sensitivity and subgroup analyses further confirmed a significant association between lower magnesium levels and a high risk of inhospital mortality. Conclusions: Decreased serum magnesium levels at admission were independently associated with in- hospital mortality in AIS patients. (C) 2017 S. Karger AG, Basel
基金：
This work was supported in part by grants from the National
Natural Science Foundation of China (81471195), Suzhou Clinical
Research Center of Neurological Disease (Szzx201503) and Jiangsu
Provincial Medical Key Discipline Project, the Second Affiliated
Hospital of Soochow University Preponderant Clinic Discipline
Group Project Funding (XKQ2015002). This work was also partly
supported by the Priority Academic Program Development of Jiangsu
Higher Education Institutions (PAPD).
