机构：[1]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.外科系统骨科首都医科大学宣武医院[2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.首都医科大学宣武医院
Osteoporosis, a prevalent bone metabolic disease, often requires long-term drug treatments that may lead to serious side effects. Trehalose, a natural disaccharide found in various organisms, has been shown to have a promoting effect on autophagy. However, whether trehalose can improve bone mass recovery in ovariectomized rats and its underlying mechanisms remains unclear. In this study, trehalose was administered to ovariectomized rats to evaluate its therapeutic potential for osteoporosis following ovariectomy.Micro-computed tomography (Micro-CT), hematoxylin and eosin (HE) and immunohistochemical staining techniques were utilized to evaluate the impact of trehalose on osteoporosis induced by ovariectomy (OVX) in mice, both in imaging and histological dimensions. Furthermore, the influence of trehalose on osteoblastogenesis and functional activity was quantified through Alizarin Red S (ARS) staining and immunoblotting assays.Trehalose effectively mitigated bone loss, elevated autophagy and suppressed pyroptosis in ovariectomized rats. Furthermore, 3-methyladenine diminished the protective effects of trehalose, particularly in promoting autophagy and inhibiting pyroptosis.Trehalose demonstrates significant potential in treating osteoporosis by suppressing NLRP3 inflammasome-driven pyroptosis, primarily through autophagy promotion. This suggests that trehalose could be a promising, safer alternative treatment for osteoporosis.
基金：
This research was funded by Post-subsidy funds for National Clinical Research Center,
Ministry of Science and Technology of China grant number [303-01-001-0272-05], Capital Medical
University Xuanwu Hospital National Natural Science Foundation Youth Cultivation grant number
[QNPY202322], R&D Program of Beijing Municipal Education Commission grant number [22JG0059]
and the key Science and Technology Project of Beijing Municipal Education Commission grant
number [KZ20231002537]. The APC was funded by [303-01-001-0272-05,QNPY202322].
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|3 区工程技术
小类|3 区生化与分子生物学3 区医学：研究与实验3 区药学
最新[2023]版：
大类|3 区工程技术
小类|3 区生化与分子生物学3 区医学：研究与实验3 区药学
JCR分区：
出版当年[2022]版：
Q1PHARMACOLOGY & PHARMACYQ2BIOCHEMISTRY & MOLECULAR BIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1PHARMACOLOGY & PHARMACYQ2BIOCHEMISTRY & MOLECULAR BIOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.[2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthopedics, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.[2]National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Hu Xinli,Wang Wei,Chen Xiaolong,et al.Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy[J].Biomedicines.2024,12(10):doi:10.3390/biomedicines12102224.
APA：
Hu Xinli,Wang Wei,Chen Xiaolong,Kong Chao,Zhao Xuan...&Lu Shibao.(2024).Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy.Biomedicines,12,(10)
MLA：
Hu Xinli,et al."Trehalose Rescues Postmenopausal Osteoporosis Induced by Ovariectomy through Alleviating Osteoblast Pyroptosis via Promoting Autophagy".Biomedicines 12..10(2024)
