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Evaluation of human epileptic brain networks by constructing simplicial complexes

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机构: [1]Yanshan Univ, Sch Informat Sci & Engn, Qinhuangdao 066004, Peoples R China [2]Yanshan Univ, Hebei Key Lab Informat Transmiss & Signal Proc, Qinhuangdao 066004, Peoples R China [3]Capital Med Univ, Xuanwu Hosp, Beijing Inst Funct Neurosurg, Beijing 100053, Peoples R China
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关键词: Simplicial complexes Euler characteristic number Synchronizability Vital nodes Epilepsy

摘要:
As a powerful framework, higher-order networks have gained significant attention to model the non-pairwise interactions of complex systems. Particularly, simplicial complex is an important mathematical tool which can be used to depict higher-order interactions. However, previous works on simplicial complexes have mainly focused on synthetic data. In this paper, we propose a method based on multivariate phase synchronization to construct simplicial complexes using multichannel stereo-electroencephalography (SEEG) data recorded from epilepsy patients. Furthermore, we examine its ability to describe both global and local characteristics of the higher-order brain network. Specifically, we first introduce the Hodge Laplacian to characterize higher-order interactions and employ the Euler characteristic number to determine the network synchronizability which is a significant global characteristic. Afterwards, we define an improved gravity-based centrality method to identify vital nodes in the higher-order network with simplicial complexes. Additionally, network efficiency based on the higher-order distance between different nodes is adopted to evaluate the effectiveness of this method in distinguishing the important nodes. In particular, we find that the Hippocampus and Fusiform gyrus may promote the synchronization of the epileptic brain network. All in all, we believe that our method paves the way to investigate brain networks with higher-order interactions, which contributes to identifying hubs in the epileptic network and has potential applications in epileptic treatment.

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出版当年[2023]版:
大类 | 1 区 数学
小类 | 1 区 数学跨学科应用 1 区 物理:数学物理 1 区 物理:综合
最新[2023]版:
大类 | 1 区 数学
小类 | 1 区 数学跨学科应用 1 区 物理:数学物理 1 区 物理:综合
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出版当年[2022]版:
Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Q1 PHYSICS, MATHEMATICAL Q1 PHYSICS, MULTIDISCIPLINARY
最新[2023]版:
Q1 PHYSICS, MULTIDISCIPLINARY Q1 MATHEMATICS, INTERDISCIPLINARY APPLICATIONS Q1 PHYSICS, MATHEMATICAL

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第一作者机构: [1]Yanshan Univ, Sch Informat Sci & Engn, Qinhuangdao 066004, Peoples R China [2]Yanshan Univ, Hebei Key Lab Informat Transmiss & Signal Proc, Qinhuangdao 066004, Peoples R China
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