Objective To investigate the effectiveness and safety of unilateral chronic hippocampus electric stimulation for temporal lobe epilepsy. Methods Five patients with temporal lobe epilepsy who were not suitable for anterior temporal lobectomy were selected. The epileptogenic zones were localized in the left temporal lobe in all the patients including 3 patients with structural lesions on the contralateral temporal lobe, 1 functional abnormality on the contralateral temporal lobe and 1 temporal lobe lesion involving language area of dominant hemispheric side. Unilateral temporal lobe seizure origin were identified by further localizing evaluation. Medtronic electrodes were implanted into the hippocampal head of epileptogenic focus side under stereotactic surgery. The chronic electric stimulation was performed after surgery. The efficacy of controlling the seizure and adverse reaction were observed. Results There was no obvious side effect after implant surgery and the chronic stimulation. During the follow-up period of 14 to 24 months, 1 patient had a seizure reduction more than 75%, 3 had a seizure reduction more than 50%and 1 did not have obvious improvement. Conclusion Chronic unilateral hippocampus electric stimulation is a safe treatment for the patients who are not suitable for anterior temporal lobectomy.