详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Exosomal miR-155-5p promote the occurrence of carotid atherosclerosis

4| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Stomatology, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China. [3]Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

出处：

DOI：

ISSN：

关键词： carotid atherosclerosis chronic periodontitis exosome LPS miR-155-5p

摘要：

Periodontitis is a significant independent risk factor for atherosclerosis. Yet, the exact mechanism of action is still not fully understood. In this study, we investigated the effect of exosomes-miR-155-5p derived from periodontal endothelial cells on atherosclerosis in vitro and in vivo. Higher expression of miR-155-5p was detected in the plasma exosomes of patients with chronic periodontitis (CP) and carotid atherosclerosis (CAS) compared to patients with CP. Also, the expression level of miR-155-5p was associated with the severity of CP. miR-155-5p-enriched exosomes from HUVECs increased the angiogenesis and permeability of HAECs and promoted the expression of angiogenesis, permeability, and inflammation genes. Along with the overexpression or inhibition of miR-155-5p, the biological effect of HUVECs-derived exosomes on HAECs changed correspondingly. In ApoE-/- mouse models, miR-155-5p-enriched exosomes promoted the occurrence of carotid atherosclerosis by increasing permeable and angiogenic activity. Collectively, these findings highlight a molecular mechanism of periodontitis in CAS, uncovering exosomal miR-155-5p derived periodontitis affecting carotid endothelial cells in an 'exosomecrine' manner. Exosomal miR-155-5p may be used as a biomarker and target for clinical intervention to control this intractable disease in future, and the graphic abstract was shown in Figure S1.© 2024 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 2 区

医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区医学：研究与实验 3 区细胞生物学

JCR分区：

出版当年[2022]版：

Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 4.3 最新[2023版] 5.1 最新五年平均 5.3 出版当年[2022版] 5.5 出版当年五年平均 5.295 出版前一年[2021版] 4.3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Stomatology, Xuanwu Hospital, Capital Medical University, Beijing, China.

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Exosomal miR-155-5p Facilitates Lipopolysaccharide Transport and Foam Cell Formation: A Novel Link Between Periodontitis and Atherosclerosis [2]Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts [3]PATHOLOGICAL-CHANGES OF OXYTALAN FIBERS IN THE HUMAN GINGIVA OF CHRONIC PERIODONTITIS [4]Treatment of carotid atherosclerosis using carotid artery stent placement [5]Pathological changes of oxytalan fibers in the human gingiva of chronic periodontitis. [6][Association of carotid atherosclerosis and blood pressure variation]. [7]Ultrasonographic micro-calcification indicate vulnerability of carotid atherosclerosis plaque [8]Relationship Between CX3CR1 Genetic Polymorphism and Carotid Atherosclerosis [9]Detection of periodontal pathogens in the patients with aortic aneurysm [10]Carotid Atherosclerosis Detected by Ultrasonography: A National Cross-Sectional Study