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Steroids' Neuroprotective Potential in Severe Cerebral Venous Thrombosis: Experimental and Clinical Exploration of NLRP3 Inflammasome Inhibition

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WOS体系：
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收录情况： ◇ SCIE

作者：
Hu Shuyuan[1,2,3] * ; Gu Yaqin[1,2] ; Hou Limin[1] ; Liu Jia[3] ; Zhao Haiping[4] ; Luo Yumin[4] ; Wang Chunxiu[5] ; Ji Xunming[2,3] ; Liu Guiyou[3] ; Duan Jiangang[1,2] ;
机构： [1]Department of Emergency, Xuanwu Hospital Capital Medical University, Beijing, China. [2]Neurology and Intracranial Hypertension &amp [3] Cerebral Venous Disease Center, National Health Commission of China, Xuanwu Hospital, Capital Medical University, Beijing, China. [3]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China. [4]Cerebrovascular Diseases Research Institute and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. [5]Department of Evidence-based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
出处：
DOI： 10.1111/cns.70125
ISSN：

关键词： cerebral venous thrombosis inflammatory response neurological injury NLRP3 inflammasome steroids

摘要：
NLRP3 inflammasome-related inflammation might play an important role in the pathophysiology of severe CVT. The use of steroids as anti-inflammatory agents in improving severe CVT prognosis remains controversial.A total of 94 male Sprague-Dawley rats were used. We evaluated the dynamic and association between NLRP3 inflammasome in brain, blood, and CSF and severity in severe CVT rats and/or patients. We also explored the effect of steroids on NLRP3 activation, neurological injury, and CSF circulation disturbance after CVT in animals and/or patients.In rats, compared with the sham group, NLRP3-related factors rose on day 1, peaked on day 2 (NLRP3, Sham: 0.79 ± 0.22; day 2: 1.25 ± 0.08, p < 0.01; pro-Caspase-1, Sham: 0.58 ± 0.13, day 2: 1.20 ± 0.44, p < 0.05; GSDMD, Sham: 0.94 ± 0.22, day 2: 1.72 ± 0.46, p < 0.05; pro-IL-1β, Sham: 0.74 ± 0.15, day 2: 1.35 ± 0.09, p < 0.01), decreased on day 7 in rats (n = 4 per group). Thrombus (Sham: 0.00 ± 0.00, day 2: 3.44 ± 0.70, p < 0.0001), infarct size (Sham: 0.00 ± 0.00, day 2: 11.99 ± 6.26, p < 0.01) and neurological deficits appeared similar trend. In 50 patients, serum NLRP3 and IL-6 levels correlated positively with NIHSS (r = 0.4273, p = 0.0020; r = 0.4938, p = 0.0029) and mRS (r = 0.5349, p = 0.0125; r = 0.6213, p = 0.026), while CSF IL-6 correlated positively with mRS on admission (r = 0.5349, p = 0.0125). Compared with baseline, NLRP3 (0.36 (0.36, 0.36) vs. 0.41 (0.37, 0.84), p < 0.0001) and IL-6 decreased (4.06 ± 1.48 vs. 12.03 ± 7.80, p < 0.05), accompanying by improvement of neurological deficits and CSF circulation (all p < 0.01) after steroids therapy in severe CVT patients at discharge and 3 months follow-up. No significant steroid-related adverse effects were observed.Short-term steroid therapy may improve prognosis of severe CVT by suppressing NLRP3 inflammasome-related inflammation.© 2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.

基金：
Beijing Municipal Natural Science Foundation, 7182064.
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 医学
小类 | 2 区 神经科学 2 区 药学
最新[2023]版：
大类 | 1 区 医学
小类 | 2 区 神经科学 2 区 药学
JCR分区：
出版当年[2022]版：
Q1 NEUROSCIENCES Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Emergency, Xuanwu Hospital Capital Medical University, Beijing, China. [2]Neurology and Intracranial Hypertension &amp [3] Cerebral Venous Disease Center, National Health Commission of China, Xuanwu Hospital, Capital Medical University, Beijing, China. [3]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
通讯作者：
通讯机构： [1]Department of Emergency, Xuanwu Hospital Capital Medical University, Beijing, China. [2]Neurology and Intracranial Hypertension &amp
推荐引用方式(GB/T 7714)：
Hu Shuyuan,Gu Yaqin,Hou Limin,et al.Steroids' Neuroprotective Potential in Severe Cerebral Venous Thrombosis: Experimental and Clinical Exploration of NLRP3 Inflammasome Inhibition[J].CNS Neuroscience & Therapeutics.2024,30(11):e70125.doi:10.1111/cns.70125.
APA：
Hu Shuyuan,Gu Yaqin,Hou Limin,Liu Jia,Zhao Haiping...&Duan Jiangang.(2024).Steroids' Neuroprotective Potential in Severe Cerebral Venous Thrombosis: Experimental and Clinical Exploration of NLRP3 Inflammasome Inhibition.CNS Neuroscience & Therapeutics,30,(11)
MLA：
Hu Shuyuan,et al."Steroids' Neuroprotective Potential in Severe Cerebral Venous Thrombosis: Experimental and Clinical Exploration of NLRP3 Inflammasome Inhibition".CNS Neuroscience & Therapeutics 30..11(2024):e70125

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