机构：[1]Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.[2]Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada.[3]Department of Radiology, University of Calgary, Calgary, AB, Canada.[4]Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.[5]Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.[6]Department of Radiology, University of British Columbia, Vancouver, BC, Canada.[7]Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.首都医科大学附属天坛医院[8]Neurological Disease Center, Beijing Anzhen Hospital, Beijing, China.首都医科大学附属安贞医院[9]Neuroscience Section, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.[10]Department of Neurology, Brown University, Providence, RI, USA.[11]Stroke Centre, Bach Mai Hospital, Ha Noi Medical University, Hanoi, Vietnam.[12]VNU University of Medicine and Pharmacy, Hanoi, Vietnam.[13]Department of Neurology, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.[14]Departments of Diagnostic and Interventional Neuroradiology, University of Tours, Tours, France.[15]Department of Stroke Neurology, National Hospital Organization Osaka National Hospital, Osaka, Japan.[16]Department of Neurology, The First Affiliated Hospital of University of Science and Technology of China, Anhui, China.[17]Department of Neurology, Klinikum Ludwigshafen, Ludwigshafen, Germany.[18]Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.[19]Dresden Neurovascular Center, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.[20]Department of Neurology, Akershus University Hospital, Lørenskog, Norway.[21]Department of Neurology, Leuven University Hospital, Leuven, Belgium.[22]Department of Neurology, The 903rd Hospital of The Chinese People's Liberation Army, Hangzhou, China.[23]Department of Neurology, Radiology, Boston University School of Medicine, Boston, MA, USA.[24]Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.[25]Department of Neurology, University of Chicago, Chicago, IL, USA.[26]Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.[27]Department of Neurology, University Hospital Bern, University of Bern, Switzerland.[28]Department of Neurology, University of Amsterdam, Academic Medical Center, Amsterdam, the Netherlands.[29]Stroke center, Lisbon Central University Hospital - ULS S José, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.[30]L Lopes lab, Instituto de Medicina Molecular, University of Lisbon, Lisbon, Portugal.[31]Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.[32]Department of Radiology, Service of Interventional Neuroradiology, Université de Montréal, Montreal, QC, Canada.[33]Department of Neurosurgery, Xuanwu Hospital, Beijing, China.神经科系统神经外科首都医科大学宣武医院[34]Stroke Outcomes Research & Decision Neuroscience Unit, Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.[35]Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Cerebral venous thrombosis (CVT) accounts for 0.5-1% of all strokes. The role of endovascular therapy (EVT) in the management of CVT remains controversial and variations in practice patterns are not well known.Here, we present a comprehensive, international characterization of practice patterns and perspectives on the use of EVT for CVT.Methods A comprehensive 42-question survey was distributed to stroke clinicians globally from May-October 2023, asking about practice patterns and perspectives on the use of EVT for CVT.The overall response rate was 31% (863 respondents of 2744 invited) across 61 countries. The majority of respondents (74%) supported the use of EVT for CVT in certain clinical situations. Key considerations for decision-making in using EVT favored clinical over radiographic/procedural factors and included worsening level of consciousness (86%) and worsening neurological deficits (76%). In the past three years, 56% of respondents used EVT for the treatment of CVT, with most (49.5%) involved in 2-5 cases. Among interventionalists, significant variability existed in the techniques used for EVT (p<0.001), with aspiration thrombectomy (56%) and stent retriever (51%) being the most used overall. Regionally, interventionalists from China predominately used intra-sinus heparin (56%), while this technique was most commonly ranked as "never indicated" throughout the rest of the world (23%). Post-procedure, low molecular weight heparin was the most used anticoagulant (83%), although North American respondents favored unfractionated heparin (37%), while imaging was primarily split between magnetic resonance (71.8%) and computed tomography (65.9%) arteriography or venography.Our survey reveals significant heterogeneity in approaches to EVT for CVT, and provides a comprehensive characterization of indications, techniques and long-term management used by clinicians internationally. This resource will aid in optimizing patient selection and endovascular treatments for future trials.
基金：
innovative clinical trials planning grant from the Canadian Institute of Health Research
第一作者机构：[1]Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
通讯作者：
推荐引用方式(GB/T 7714)：
Brakel Benjamin Arnold,Rebchuk Alexander D,Ospel Johanna,et al.International practice patterns and perspectives on endovascular therapy for the treatment of cerebral venous thrombosis[J].International Journal Of Stroke : Official Journal Of The International Stroke Society.2025,20(3):319-327.doi:10.1177/17474930241304206.
APA：
Brakel Benjamin Arnold,Rebchuk Alexander D,Ospel Johanna,Chen Yimin,Heran Manraj Ks...&Field Thalia Shoshana.(2025).International practice patterns and perspectives on endovascular therapy for the treatment of cerebral venous thrombosis.International Journal Of Stroke : Official Journal Of The International Stroke Society,20,(3)
MLA：
Brakel Benjamin Arnold,et al."International practice patterns and perspectives on endovascular therapy for the treatment of cerebral venous thrombosis".International Journal Of Stroke : Official Journal Of The International Stroke Society 20..3(2025):319-327
