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Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1): A Potential Therapeutic Target in Ischemic Stroke

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收录情况： ◇ SCIE

作者：

机构： [1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center, Beijing, China [3]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

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关键词： LOX-1 Cerebral ischemia Stroke sLOX-1

摘要：

Stroke, the leading cause of disability and the second leading cause of death worldwide, is characterized by high morbidity and disability. The lectin-like oxidized low-density lipoprotein receptor (LOX-1) is a scavenger receptor that promotes endothelial dysfunction by recognizing and internalizing oxidized low-density lipoproteins (ox-LDL) to induce the formation, development, and instability of atherosclerotic plaques, ultimately leading to vascular thrombosis. Previous clinical and epidemiological studies have indicated that LOX-1 plays a vital role in cerebral ischemic injury following ischemic stroke. Multiple clinical studies have shown that the genetic polymorphisms in LOX-1 are associated with susceptibility to ischemic stroke. Soluble LOX-1 (sLOX-1), a biomarker of ischemic stroke, is associated with the prognosis of ischemic stroke. This article discusses the clinical and experimental findings on LOX-1 in ischemic stroke and the development of new therapeutic strategies targeting LOX-1.© 2024. The Author(s).

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区临床神经病学 2 区神经科学

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出版当年[2022]版：

Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

影响因子： 3.8 最新[2023版] 5.1 最新五年平均 6.9 出版当年[2022版] 6.5 出版当年五年平均 6.8 出版前一年[2021版] 3.8 出版后一年[2023版]

第一作者：

第一作者机构： [1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China

通讯作者：

通讯机构： [1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [2]Beijing Geriatric Medical Research Center, Beijing, China [3]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China

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