机构：[1]Department of Psychiatry, University of Cambridge, Cambridge CB22QQ, UK.[2]Zhejiang Key Laboratory of Multi-Omics in Infection and Immunity, Center for Infectious Disease Research, School of Medicine, Westlake University, Xihu District, Hangzhou 310024, China.[3]Research Center for Industries of the Future, School of Life Sciences, Westlake University, Xihu District, Hangzhou 310024, China.[4]Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE17RU, UK.[5]Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.[6]Beijing Xuanwu Hospital, Capital Medical University, Beijing 100088, China.首都医科大学宣武医院[7]Department of Neuroscience, Neuroscience Institute, Insigneo Institute for In Silico Medicine, University of Sheffield, Sheffield S102TN, UK.
Background: Attention deficits are notable in Lewy body dementia (LBD) and in Alzheimer's disease (AD). In this study, we combined functional magnetic resonance imaging (fMRI) and electroencephalograph (EEG) to detect neural correlates of attention dysfunctions in LBD and AD. Methods: We recruited 33 patients with LBD, 15 patients with AD and 19 elderly healthy controls. The participants performed the modified Attention Network Task (ANT) to investigate the attention dysfunctions. Results: We found that LBD had alerting attention deficits and AD showed apparent orienting attention dysfunctions, while LBD and AD maintained relatively normal executive/conflict attention. Based on source-level EEG analyses, LBD had frontal-central deficits for alerting attention while AD showed inferior frontal and precentral impairments for orienting attention. In addition, the insular and inferior frontal areas were hyper-activated in LBD and AD for executive/conflict attention. Apart from these areas, LBD showed activity in the complementary temporal-central-occipital network for the modified ANT task. Furthermore, the oscillational sources for the ANT effects indicated that the alpha and theta bands were partly impaired in dementia patients. Conclusions: In summary, using source-localised EEG, we found that attention dysfunctions in LBD and AD engaged different neural networks.
基金：
Alzheimer’s Research UK Senior Research Fellowship [ARUKSRF2017B-1]; Y.H. was funded by the National Natural Science Foundation of China under Grant [71702169]; Ruth Cromarty was funded by the Alzheimer’s Research UK; J.-P.T. was funded by the Wellcome Trust Fellowship (WT088441MA).
第一作者机构：[1]Department of Psychiatry, University of Cambridge, Cambridge CB22QQ, UK.[2]Zhejiang Key Laboratory of Multi-Omics in Infection and Immunity, Center for Infectious Disease Research, School of Medicine, Westlake University, Xihu District, Hangzhou 310024, China.[3]Research Center for Industries of the Future, School of Life Sciences, Westlake University, Xihu District, Hangzhou 310024, China.
通讯作者：
通讯机构：[1]Department of Psychiatry, University of Cambridge, Cambridge CB22QQ, UK.[7]Department of Neuroscience, Neuroscience Institute, Insigneo Institute for In Silico Medicine, University of Sheffield, Sheffield S102TN, UK.
推荐引用方式(GB/T 7714)：
Huang Yujing,Cromarty Ruth,Jia Lina,et al.Attention Network Dysfunctions in Lewy Body Dementia and Alzheimer's Disease[J].Journal Of Clinical Medicine.2024,13(22):doi:10.3390/jcm13226691.
APA：
Huang Yujing,Cromarty Ruth,Jia Lina,Han Ying,O'Brien John...&Su Li.(2024).Attention Network Dysfunctions in Lewy Body Dementia and Alzheimer's Disease.Journal Of Clinical Medicine,13,(22)
MLA：
Huang Yujing,et al."Attention Network Dysfunctions in Lewy Body Dementia and Alzheimer's Disease".Journal Of Clinical Medicine 13..22(2024)
