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Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage

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收录情况： ◇ SCIE

作者：
Li Jiaxin[1] * ; Hao Gaimei[1] * ; Yan Yupeng[1] * ; Li Ming[2] ; Li Gaifen[1] ; Lu Zhengmin[1] ; Sun Zhibo[1] ; Chen Yanjing[1] ; Liu Haixia[1] ; Zhao Yukun[1] ; Wu Meng[1] ; Bao Xiangxin[1] ; Wang Yong[3] ; Li Yubo[1] ;
机构： [1]Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China [2]Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [3]Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100029, China
出处：
DOI： 10.1016/j.neuint.2024.105914
ISSN：

关键词： Depression Chronic mild unpredictable stress Hydrogen Mitochondrial biogenesis Mitochondrial autophagy

摘要：
The field of hydrogen medicine has garnered extensive attention since Professor Ohsawa established that low concentrations of hydrogen (2%-4%) exert antioxidant effects. The present study aimed to evaluate the therapeutic effect of molecular hydrogen in a CUMS rat model.A total of 40 SD rats were randomly divided into a control group, a model group, a hydrogen group, and a positive drug group. Four weeks post-modeling, hydrogen inhalation and other treatments were administered. Behavioral, biochemical, and immunohistochemical evaluations were performed after treatment.Hydrogen inhalation alleviated depressive behavior and hippocampal neuronal damage in CUMS rats, as well as restored the levels of neurotransmitters, inflammatory factors, and oxidative stress. Moreover, it maintained mitochondrial homeostasis and up-regulated the expression of PGC-1α, PINK1, and Parkin.The results collectively indicated that hydrogen significantly attenuated CUMS-induced depressive-like behavior and monoamine neurotransmitter deficiency, as well as protected the brain from oxidative stress and inflammatory damage and effectively preserved mitochondrial homeostasis.Copyright © 2024 Elsevier Ltd. All rights reserved.

基金：
This work was supported by the TCM Theory Inheritance and Innovation Project of CACMS Innovation Fund (Grant No.KYG-202403); National Natural Science Foundation of China (Grant No. 81603417); The Fundamental Research Funds for the Central Public Welfare Research Institutes (Grant No.YZX-202228).
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外文
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中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 生化与分子生物学 3 区 神经科学
JCR分区：
出版当年[2023]版：
Q1 NEUROSCIENCES Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1 NEUROSCIENCES Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Jiaxin,Hao Gaimei,Yan Yupeng,et al.Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage[J].Neurochemistry International.2025,182:105914.doi:10.1016/j.neuint.2024.105914.
APA：
Li Jiaxin,Hao Gaimei,Yan Yupeng,Li Ming,Li Gaifen...&Li Yubo.(2025).Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage.Neurochemistry International,182,
MLA：
Li Jiaxin,et al."Hydrogen restores central tryptophan and metabolite levels and maintains mitochondrial homeostasis to protect rats from chronic mild unpredictable stress damage".Neurochemistry International 182.(2025):105914

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