机构：[1]Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统科技平台神经内科中美神经科学研究所首都医科大学宣武医院[2]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China[3]Interdisciplinary Innovation Institute of Medicine and Engineering Interdisciplinary, Beihang University, Beijing, China[4]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经外科首都医科大学宣武医院
Mitochondria play a central role in the pathophysiological processes of acute ischemic stroke. Disruption of the cerebral blood flow during acute ischemic stroke interrupts oxygen and glucose delivery, leading to the dysfunction of mitochondrial oxidative phosphorylation and cellular bioenergetic stress. Cells can respond to such stress by activating mitochondrial quality control mechanisms, including the mitochondrial unfolded protein response, mitochondrial fission and fusion, mitophagy, mitochondrial biogenesis, and intercellular mitochondrial transfer. Collectively, these adaptive response strategies contribute to retaining the integrity and function of the mitochondrial network, thereby helping to recover the homeostasis of the neurovascular unit. In this review, we focus on mitochondrial quality control mechanisms occurring in acute ischemic stroke. A better understanding of how these regulatory pathways work in maintaining mitochondrial homeostasis will provide a rationale for developing innovative neuroprotectants when these mechanisms fail in acute ischemic stroke.
基金：
This work was supported by Beijing Natural Science
Foundation (7192103); National Natural Science Foundation
of China (81971198); Chinese Ministry of science and
Technology (2019YFA0508603), China; and National
Natural Science Foundation of China (82027802).
第一作者机构：[1]Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China[3]Interdisciplinary Innovation Institute of Medicine and Engineering Interdisciplinary, Beihang University, Beijing, China[4]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China[*1]Beihang University, 37 Xueyuan Road, Haidian District, Beijing 100191, China[*2]Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China
推荐引用方式(GB/T 7714)：
An Hong,Zhou Bing,Ji Xunming.Mitochondrial quality control in acute ischemic stroke.[J].JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.2021,41(12):3157-3170.doi:10.1177/0271678X211046992.
APA：
An Hong,Zhou Bing&Ji Xunming.(2021).Mitochondrial quality control in acute ischemic stroke..JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,41,(12)
MLA：
An Hong,et al."Mitochondrial quality control in acute ischemic stroke.".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 41..12(2021):3157-3170
医学