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Lactate Ameliorates Kainic Acid-Induced Neuroinflammation and Cognitive Impairment via the Chemokine Signaling Pathway in Mice

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机构： [1]Optometry Institute, School of Medicine Nankai University, Tianjin, People's Republic of China. [2]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China. [3]Department of Neurology, The Second Hospital of Dalian Medical University, Dalian, People's Republic of China. [4]Cancer Center, Capital Medical University, Beijing, People's Republic of China. [5]Central Laboratory, Xuanwu Hospital Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China. [6]Department of Pathology, School of Medicine Nankai University, Tianjin, People's Republic of China. [7]National Medical Center for Neurological Diseases, Beijing, People's Republic of China.

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关键词： lactate neuroinflammation cognitive impairment neuronal damage chemokine epilepsy

摘要：

Lactate, previously considered a metabolic waste product, has been shown to have neuroprotective potential. This study aims to investigate the impact of lactate intervention and its underlying mechanisms on epilepsy.HT22 cells were stimulated with glutamate to construct an excitotoxicity cell model. An acute epilepsy model was established in mice by kainic acid induction. The neuronal damage, microglial activation, inflammatory responses, and functional changes were determined by TUNEL assays, immunohistochemistry, quantitative real-time polymerase chain reaction and behavioral tests. The differentially gene expression and functional enrichment were analyzed with RNA sequencing.The in vitro lactate intervention reduced the number of apoptotic cells, the release of inflammatory factors, and the expression of vesicular glutamate transporter 1. In mice with acute epilepsy, lactate treatment mitigated neuronal damage, microglial activation, and inflammatory responses in the hippocampus and ameliorated anxiety-like behavior and cognitive impairment.Lactate exerts therapeutic effects on epilepsy through the chemokine signaling pathway. The neuroinflammation is an important contributor to cognitive impairment. Targeting inflammatory pathways is a promising strategy for improving the prognosis of epilepsy.© 2025 Chu et al.

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出版当年[2025]版：

大类 | 3 区医学

小类 | 3 区免疫学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区免疫学

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出版当年[2023]版：

Q2 IMMUNOLOGY

最新[2023]版：

Q2 IMMUNOLOGY

影响因子： 4.2 最新[2023版] 4.6 最新五年平均 4.2 出版当年[2023版] 4.6 出版当年五年平均 4.5 出版前一年[2022版]

第一作者：

第一作者机构： [1]Optometry Institute, School of Medicine Nankai University, Tianjin, People's Republic of China. [2]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China.

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通讯作者：

通讯机构： [2]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China. [5]Central Laboratory, Xuanwu Hospital Capital Medical University, Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China. [6]Department of Pathology, School of Medicine Nankai University, Tianjin, People's Republic of China. [7]National Medical Center for Neurological Diseases, Beijing, People's Republic of China.

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