机构：[a]Department of Senile Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, PR China[b]Department of Anti-Ageing, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, PR China[c]Department of KI-Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, 14186, Sweden[d]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, 100053, PR China神经内科首都医科大学宣武医院[e]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, PR China
Fructose intake is linked with the increasing prevalence of insulin resistance, and insulin resistance links Alzheimer's disease with impaired insulin signaling, oxidative damage, neuroinflammation, and cognitive impairment. As a member of the carotenoid family of phytochemicals, lycopene is used as a potent free scavenger, and has been demonstrated to be effective in anti-oxidative stress and anti-inflammatory reaction in the models of AD and other neurodegenerative diseases. Here, we investigated the effect of lycopene on learning and memory impairment and the possible underlying molecular events in fructose-drinking insulin resistant rats. We found that long-term fructose-drinking causes insulin resistance, impaired insulin signaling, oxidative stress, neuroinflammation, down-regulated activity of cholinergic system, and cognitive impairment, which could be significantly ameliorated by oral lycopene administration. The results from this study provide experimental evidence for using lycopene in the treatment of brain damage caused by fructose-drinking insulin resistance. (C) 2014 Elsevier Ltd. All rights reserved.
基金：
Research program to tackle key problems of Shandong Province, P.R. China (2006GGB14630; 2011YD18081)
第一作者机构：[a]Department of Senile Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, PR China
通讯作者：
通讯机构：[*1]Department of Senile Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, PR China.[*2]Department of NVS, KI-Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, 14186, Sweden.
推荐引用方式(GB/T 7714)：
Qingqing Yin,Yingjuan Ma,Yan Hong,et al.Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats[J].NEUROPHARMACOLOGY.2014,86:389-396.doi:10.1016/j.neuropharm.2014.07.020.
