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Insulin resistance and cognitive dysfunction

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Geriatrics, XuanWu Hospital, Capital Medical University, Beijing 100053, China

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关键词： Insulin resistance Mild cognitive impairment Insulin Alzheimer's disease

摘要：

Epidemiologic and biologic studies support a link between type 2 diabetes mellitus and Alzheimer's disease, but the precise mechanism linking the two remains unclear. Growing evidence supports the concept that insulin resistance is important in the pathogenesis of cognitive impairment and neurodegeneration. Insulin plays a profound role in cognitive function. Impaired insulin signaling in the advancement of cognitive dysfunction is relevant to the pathophysiologic mechanisms of cognitive impairment. In this paper we discuss the relationship between insulin resistance and cognitive impairment and review potential mechanisms of this disease process. Evidence, to date, suggests that brain insulin resistance is an independent risk factor for cognitive impairment. (C) 2015 Elsevier B.V. All rights reserved.

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出版当年[2014]版：

大类 | 3 区医学

小类 | 2 区医学实验技术

最新[2023]版：

大类 | 3 区医学

小类 | 3 区医学实验技术

JCR分区：

出版当年[2013]版：

Q1 MEDICAL LABORATORY TECHNOLOGY

最新[2023]版：

Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 3.2 最新[2023版] 3.7 最新五年平均 2.764 出版当年[2013版] 2.748 出版当年五年平均 2.85 出版前一年[2012版] 2.824 出版后一年[2014版]

第一作者：

第一作者机构： [1]Department of Geriatrics, XuanWu Hospital, Capital Medical University, Beijing 100053, China

通讯作者：

通讯机构： [*1]Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, #45 Changchun Street, Xicheng District, Beijing 100053, China.

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