Articular cartilage lesion frequently leads to dysfunction and the development of degenerative diseases, posing a significant public health challenge due to the limited self-healing capacity of cartilage tissue. Current surgical treatments, including marrow stimulation techniques and osteochondral autografts/allografts, have limited efficacy or have significant drawbacks, highlighting the urgent need for alternative strategies. Advances in 3D printing for cartilage regeneration have shown promising potential in creating cartilage-mimicking constructs, thereby opening new possibilities for cartilage repair. In this review, we summarize current surgical treatment methods and their limitations for addressing articular cartilage lesion, various 3D printing strategies and their features in cartilage tissue engineering, seed cells from different sources, and different types of biomaterials. We also explore the benefits, current challenges, and future research directions for 3D printing in the treatment of articular cartilage lesion within the field of cartilage tissue engineering.
基金:
Capital Clinical Diagnosis and Treatment Technology Research and Transformation Application Fund Project [Z201100005520091]; Beijing Traditional Chinese Medicine Science and Technology Development Fund Project [JJ-2020- 67]
第一作者机构:[1]Capital Med Univ, Xuanwu Hosp, Dept Orthoped, 45,Changchun St, Beijing, Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Tao Haicheng,Feng Mingli,Feng Hui,et al.Research advance of 3D printing for articular cartilage regeneration[J].REGENERATIVE MEDICINE.2025,doi:10.1080/17460751.2025.2466346.
APA:
Tao, Haicheng,Feng, Mingli,Feng, Hui&Ren, Hongchen.(2025).Research advance of 3D printing for articular cartilage regeneration.REGENERATIVE MEDICINE,,
MLA:
Tao, Haicheng,et al."Research advance of 3D printing for articular cartilage regeneration".REGENERATIVE MEDICINE .(2025)