To derive critical signal features from intracranial electroencephalograms of epileptic patients in order to design instructions for feedback-type electrical stimulation systems. The Detrended Fluctuation Analysis (DFA) exponent is chosen as the classification exponent, and the disparities between indicators representing distinct seizure states and the classification efficacy of rudimentary machine learning models are computed. The DFA exponent exhibited a statistically significant variation among the pre-ictal, ictal period, and post-ictal stages. The Linear Discriminant Analysis model demonstrates the highest accuracy among the three basic machine learning models, whereas the Naive Bayesian model necessitates the least amount of computational and storage space. The set of DFA exponents is employed as an intermediary variable in the machine learning process. The resultant model possesses the capability to function as a feedback trigger program for electrical stimulation systems of the feedback variety, specifically within the domain of neural modulation in epilepsy.
基金:
Key Project of Beijing Mu-nicipal Commission of Science and Technology [Z221100007422016]; Joint Project of Beijing Natural Science Foundation [L222107]; Sailing Project of Beijing Hospitals Authority in Clinical Medicine Development [ZLRK202319]
第一作者机构:[1]Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China[4]Capital Med Univ, Lab Brain Inspired Intelligence, Beijing 100053, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China[2]Chinese Acad Sci, Lab Brain Atlas & Brain Inspired Intelligence, Inst Automat, Beijing 100190, Peoples R China[3]Capital Med Univ, Clin Res Ctr Epilepsy, Beijing 100053, Peoples R China[4]Capital Med Univ, Lab Brain Inspired Intelligence, Beijing 100053, Peoples R China[5]Univ Chinese Acad Sci, Sch Future Technol, Beijing 101408, Peoples R China
推荐引用方式(GB/T 7714):
Yu Zhikai,Yang Binghao,Wei Penghu,et al.Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field[J].FUNDAMENTAL RESEARCH.2025,5(1):103-114.doi:10.1016/j.fmre.2024.05.018.
APA:
Yu, Zhikai,Yang, Binghao,Wei, Penghu,Xu, Hang,Shan, Yongzhi...&Zhao, Guoguang.(2025).Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field.FUNDAMENTAL RESEARCH,5,(1)
MLA:
Yu, Zhikai,et al."Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field".FUNDAMENTAL RESEARCH 5..1(2025):103-114